Document Detail


Circulating levels of endothelin-1 in a homogenous Gulf Arab population with untreated essential hypertension.
MedLine Citation:
PMID:  17019099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Racial variations are reported in the natural history of hypertension. For example, hypertension is significantly more prevalent in blacks than whites. Endothelial cells are important regulators of vascular tone and homeostasis, in part through secretions of vasoactive substances including endothelin-1 (ET-1), a small peptide with potent vasopressor actions. In black hypertensives, ET-1 levels are higher than in normotensive blacks and in both hypertensive and normotensive whites. Since ET-1 might play a significant role in the development and severity of hypertension in the indigenous Arab population of the United Arab Emirates, we investigated the circulating levels of ET-1 in this homogenous population. PATIENTS AND METHODS: ET-1 levels were measured in plasma samples from 60 untreated hypertensive Arabs and compared with 60 age- and sex-matched normotensive controls. RESULTS: ET-1 levels were significantly higher in hypertensives (mean 10.1 +/- 1 pmol/L) than normotensives (mean 2.2 +/- 0.5 pmol/L). Body mass index (BMI) was slightly higher among the hypertensives. For all subjects these levels significantly (P < 0.001) correlated with systolic blood pressure and less significantly (P < 0.05) with diastolic blood pressure and body weight. The correlation between ET-1 and both systolic and diastolic blood pressure was persistently significant after adjusting for BMI. CONCLUSION: Plasma concentrations of ET-1 are significantly higher in hypertensive Gulf Arabs as compared with reported levels in white hypertensives and ET-1 could be a risk factor for cardiovascular diseases in this population. The endothelial system might be particularly important with respect to hypertension in this racial group and merits further study.
Authors:
Enyioma Obineche; Abdishakur M Abdulle; Awais M Bokhari; Javed Y Yasin; Michael P T Gillett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  26     ISSN:  0256-4947     ISO Abbreviation:  Ann Saudi Med     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-04     Completed Date:  2007-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Faculty of Medicine & Health Sciences, UAE University, Al Ain, Abu Dhabi, United Arab Emirates. eobineche@uaeu.ac.ae
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MeSH Terms
Descriptor/Qualifier:
Adult
Arabs / statistics & numerical data*
Biological Markers / blood
Blood Glucose / metabolism
Blood Pressure
Body Mass Index
Case-Control Studies
Endothelin-1 / blood*
Female
Humans
Hypertension / blood*,  ethnology*,  physiopathology
Insulin / blood
Logistic Models
Male
Middle Aged
Multivariate Analysis
Severity of Illness Index
United Arab Emirates / epidemiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Endothelin-1; 11061-68-0/Insulin
Comments/Corrections
Comment In:
Ann Saudi Med. 2006 Sep-Oct;26(5):343-5   [PMID:  17019103 ]

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