Document Detail

Circulating levels of ciliary neurotrophic factor in normal pregnancy and preeclampsia.
MedLine Citation:
PMID:  20424668     Owner:  NLM     Status:  MEDLINE    
Ciliary neurotrophic factor (CNTF) has been shown to decrease food intake in mouse models of obesity and to improve insulin sensitivity. It is well known that tight regulation of glucose metabolism is essential for successful gestational outcomes (e.g. fetal growth), and that abnormal insulin resistance is associated with preeclampsia (PE). To investigate the possibility that CNTF might be involved in the regulation of insulin resistance during pregnancy, circulating levels of CNTF were assessed in non-pregnant, normal pregnant, postpartum, and pregnant women with PE. Sera from healthy non-pregnant women (n = 10), pregnant women (n = 30:1st trimester; n = 10, 2nd trimester n = 10; 3rd trimester; n = 10), postpartum women (n = 10), and patients with PE (n = 11) were studied with Western blotting. Circulating CNTF was detected by Western blotting, and the levels of CNTF in pregnant women were decreased as compared with those in non-pregnant women, and tended to decrease as pregnancy progressed. A significant decrease was found in PE as compared with normal pregnancy. Circulating CNTF might be associated with physiological and abnormal insulin resistance during pregnancy.
Yoichiro Akahori; Norio Takamoto; Akio Masumoto; Seiji Inoue; Hideki Nakatsukasa; Hisashi Masuyama; Yuji Hiramatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Okayama     Volume:  64     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
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MeSH Terms
Body Mass Index
Ciliary Neurotrophic Factor / blood*
Pre-Eclampsia / blood*
Pregnancy / blood*
Pregnancy Trimester, Third
Weight Gain
Reg. No./Substance:
0/Ciliary Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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