| Circulating levels of adiponectin in preterm infants. | |
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MedLine Citation:
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PMID: 17074785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. DESIGN: Prospective study. SETTING: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group). INTERVENTIONS: Blood samples taken at discharge (40.9 (14.8) days of life) from the preterm infants and at a comparable postnatal age in full-term infants. All infants were fed the same commercial formula, but in nine preterms the formula contained long-chain polyunsaturated fatty acids (LCPUFAs). MAIN OUTCOME MEASURES: Serum levels of adiponectin, leptin and insulin. Associations of adiponectin levels were tested only in the preterm group. RESULTS: Serum levels of adiponectin were lower in preterm (40.9 (14.8) microg/ml) than full-term infants (53.1 (16.0) microg/ml, p<0.01). However, after adjustment for body weight, the influence of prematurity on adiponectin levels was no longer significant. In preterm infants, adiponectin levels independently correlated with being born small for gestational age (SGA) (beta=-0.35, p=0.01), weight gain (beta=0.28, p=0.03) and LCPUFA-supplemented formula (beta=0.34, p=0.009). Serum adiponectin levels did not correlate with insulin or leptin levels. However, insulin levels were higher in preterm than in full-term infants after adjustment for body weight. CONCLUSIONS: Adiponectin levels are lower in preterm infants at discharge than full-term infants probably due to decreased adiposity. The levels are influenced by being born SGA, weight gain and, possibly, by dietary LCPUFAs. The importance of these findings in the development of insulin or leptin resistance in children born prematurely needs to be further studied. |
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Authors:
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Tania Siahanidou; Helen Mandyla; Gerasimos-Peter Papassotiriou; Ioannis Papassotiriou; George Chrousos |
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Publication Detail:
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Type: Journal Article Date: 2006-10-30 |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 92 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-22 Completed Date: 2007-07-12 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F286-90 Citation Subset: AIM; IM |
Affiliation:
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First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, 115 27 Athens, Greece. neonat5@paidon-agiasofia.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Anthropometry / methods Birth Weight / physiology Body Weight / physiology Female Gestational Age Humans Infant, Newborn Infant, Premature / blood* Insulin / blood Leptin / blood Male Prospective Studies Weight Gain / physiology |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Leptin; 11061-68-0/Insulin |
| Comments/Corrections | |
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