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Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women.
MedLine Citation:
PMID:  21135066     Owner:  NLM     Status:  In-Data-Review    
Objective In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects. Design Cross-sectional analysis in two different cohorts composed of middle-aged- (n=672, mean 63.9±6.7 years) and oldest-old subjects (n=272, all 89 years). Methods Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately. Results IGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged- and oldest-old women (both, P<0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldest-old men (P=0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (P=0.002). Conclusion The significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.
Diana G Taekema; Carolina H Y Ling; Gerard Jan Blauw; Carel G Meskers; Rudi G J Westendorp; Anton J M de Craen; Andrea B Maier
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Publication Detail:
Type:  Journal Article     Date:  2010-12-06
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  164     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Department of Gerontology and Geriatrics, C2-R-133, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands Department of Geriatrics, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The Netherlands Department of Rehabilitation Medicine Netherlands Consortium for Healthy Aging, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
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