Document Detail

Circulating leukotriene B4 identifies respiratory complications after trauma.
MedLine Citation:
PMID:  22529525     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients.
METHODS: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC).
RESULTS: LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104-200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55-143 pg/mL] or control-group [58.4 pg/mL, IQR: 36-108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay.
CONCLUSION: High LTB4-levels indicate risk for PC development in multiply traumatized patients.
Birgit Auner; Emanuel V Geiger; Dirk Henrich; Mark Lehnert; Ingo Marzi; Borna Relja
Related Documents :
9649185 - Decay-accelerating factor (daf) in stool specimens as a marker of disease activity in p...
19255845 - Impact of capsule endoscopy findings in the management of crohn's disease.
10950045 - High prevalence of celiac sprue-like hla-dq genes and enteropathy in patients with the ...
16607145 - Colonic propulsive and postprandial motor activity in patients with ulcerative colitis ...
7092185 - Multiple sclerosis: trial of a synthetic polypeptide.
11948045 - Noninvasive positive-pressure ventilation vs. conventional oxygen supplementation in hy...
Publication Detail:
Type:  Journal Article     Date:  2012-03-07
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  536156     Citation Subset:  IM    
Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Goethe University Frankfurt am Main, 60590 Frankfurt, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Lung Injury / blood*,  classification
Blood Transfusion
Enzyme-Linked Immunosorbent Assay / methods
Intensive Care
Leukotriene B4 / blood*
Lung Diseases / complications
Middle Aged
Respiratory Distress Syndrome, Adult / blood*,  complications
Sensitivity and Specificity
Time Factors
Wounds and Injuries / complications*,  diagnosis
Reg. No./Substance:
71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The anti-inflammatory cytokine, interleukin-10, inhibits inflammatory mediators in human epithelial ...
Next Document:  Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after ...