Document Detail

Circulating leptin level and growth hormone response to stimulation tests in obese and normal children.
MedLine Citation:
PMID:  9916863     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Growth hormone secretion is decreased in obese subjects, and their GH response to stimulation tests is blunted. The mechanisms relating excess adipose mass and GH secretion are unknown. We hypothesized that leptin might be a signal linking adipose mass to GH secretion. DESIGN: We measured serum leptin levels and the GH response to stimulation tests in 42 obese and 40 lean short normal prepubertal children. RESULTS: The mean serum leptin concentrations were 23.8+/-1.7 ng/ml and 3.6+/-0.4 ng/ml in obese and lean children respectively, and were found to be inversely related to GH peak in both groups. After adjusting for body fat data, leptin was still an independent predictor of GH peak. Multiple stepwise regression analysis identified both leptin (regression coefficient = -0.78, P = 0.001), and insulin (regression coefficient = -0.03. P = 0.009) as negative determinants of GH response to the GHRH test in obese children (multiple R = 0.64), and only leptin in lean children (r = -0.51, P = 0.001). No correlation was observed between leptin and IGF-I or IGF binding protein-3. CONCLUSION: These results are consistent with the hypothesis that leptin could contribute to the regulation of GH secretion.
R Coutant; N Lahlou; C Bouvattier; P Bougnères
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  139     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  591-7     Citation Subset:  IM    
Pediatric Endocrinology and U 342 INSERM, Saint Vincent de Paul Hospital, René Descartes University, Paris, France.
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MeSH Terms
Body Height
Case-Control Studies
Child, Preschool
Growth Hormone-Releasing Hormone / diagnostic use*
Human Growth Hormone / secretion*
Insulin-Like Growth Factor I / metabolism
Obesity / blood*
Proteins / metabolism*
Reference Values
Secretory Rate / drug effects
Stimulation, Chemical
Reg. No./Substance:
0/Leptin; 0/Proteins; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; 9034-39-3/Growth Hormone-Releasing Hormone

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