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Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events.
MedLine Citation:
PMID:  24916788     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction:Irisin is a newly discovered myokine, associated with «browning» of the white adipose tissue, obesity, insulin resistance and metabolic syndrome. The purpose of this study is to evaluate circulating irisin as predictor of acute coronary syndromes (ACS) and major adverse cardiovascular events (MACE).Methods:Sub-study 1: a case control study, nested within the Veteran's Affairs Normative Ageing Study, evaluating circulating irisin levels in 88 ACS cases and 158 age- and sampling year-matched controls, as a predictor of ACS. Sub-study 2: a prospective cohort study where 103 participants with established coronary artery disease were stratified by circulating irisin levels at the time they received percutaneous coronary interventions and were followed for the development of MACE.Results:Study 1: There was no association between irisin levels and ACS in otherwise healthy individuals (OR: 1.00 95%CI: [0.99-1.00]). Study 2: the incidence of MACE was significantly lower in the first irisin tertile compared to the second and third (incidence rate 0 vs. 0.92 [0.51-1.61] vs 0.57 [0.28-1.14] events per 1000 person-days; P<0.01). This was primarily driven by the lower incidence of unstable angina (incidence rate 0 vs 0.61 [0.31-1.22] vs. 0.43 [0.19-0.96] per 1000 person-days; P=0.01).Conclusion:This is the first study to date that demonstrates that although circulating irisin levels do not predict the development of ACS in healthy individuals, increased irisin levels are associated with the development of MACE in patients with established coronary artery disease after PCI.International Journal of Obesity accepted article preview online, 11 June 2014; doi:10.1038/ijo.2014.101.
Authors:
K N Aronis; M Moreno; S A Polyzos; J M Moreno-Navarrete; W Ricart; E Delgado; J de la Hera; A Sahin-Efe; J P Chamberland; R Berman; A Spiro; P Vokonas; J Manuel-Fernández-Real; C S Mantzoros
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-11
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  -     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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