Document Detail

Circulating irisin in healthy, young individuals: Day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet and body composition.
MedLine Citation:
PMID:  24915120     Owner:  NLM     Status:  Publisher    
Context: The myokine irisin may increase energy expenditure and affect metabolism. Objective: To elucidate predictors of irisin and study whether circulating irisin may have day-night rhythm in humans. Design: Observational, cross-sectional study with an additional 24h prospective observational arm (Day-night rhythm sub-study) and two prospective interventional arms (Mixed meal sub-study and Exercise sub-study). Setting: The Hellenic Military School of Medicine, Thessaloniki, Greece. Patients and Interventions: One hundred twenty-two healthy, young individuals were subjected to anthropometric and body composition measurements and their eating and exercise behavior profiles were assessed with validated questionnaires. Sub-groups were subjected to day night rhythm, standardized meal ingestion and 30-min aerobic exercise studies. Main outcome measures: Circulating irisin levels. Results: Irisin levels were lower in males than females (p=0.02) after adjustment for lean body mass (LBM), which was its major determinant. Irisin levels followed a day-night rhythm (p<0.001) with peak at 9 pm. Irisin levels were increased at the end of exercise (84.1 ± 10.0 vs. 105.8 ± 14.3 ng/mL; p<0.001). Irisin levels were not affected by intake of a standardized meal and were not associated with caloric intake or diet quality. Conclusions: In healthy, young individuals circulating irisin displays a day-night rhythm, is correlated with lean body mass and increases acutely after exercise.
Athanasios D Anastasilakis; Stergios A Polyzos; Zacharias G Saridakis; Georgios Kynigopoulos; Elpida C Skouvaklidou; Dimitrios Molyvas; Maria F Vasiloglou; Aggeliki Apostolou; Thomai Karagiozoglou-Lampoudi; Aikaterina Siopi; Vasillis Mougios; Panagiotis Chatzistavridis; Grigorios Panagiotou; Andreas Filippaios; Sideris Delaroudis; Christos S Mantzoros
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  jc20141367     Citation Subset:  -    
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