| Circulating interleukin-6 receptor in patients with sepsis syndrome. | |
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MedLine Citation:
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PMID: 7661926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptor (sTNFR) p55 and p75 were measured in 25 patients with sepsis syndrome. Sequential blood samples were drawn from patients during a 7-h period. IL-6 concentrations were 34-763,000 pg/mL; they were higher in nonsurvivors than survivors, but the difference was not statistically significant. In septic patients, the median sIL-6R concentration was significantly lower than in 19 healthy volunteers (43 vs. 80 ng/mL). sIL-6R concentrations in survivors were not significantly different than those in nonsurvivors. There was a negative correlation between IL-6 and sIL-6R in septic patients (r = -.72). In patients with moderately impaired renal function, sIL-6R levels were not affected, but the concentrations of sTNFRs were significantly higher. |
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Authors:
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J T Frieling; M van Deuren; J Wijdenes; J W van der Meer; C Clement; C J van der Linden; R W Sauerwein |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 171 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-09 Completed Date: 1995-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 469-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University Hospital Nijmegen, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antigens, CD* Female Humans Interleukin-6 / blood* Male Middle Aged Receptors, Interleukin / analysis* Receptors, Interleukin-6 Receptors, Tumor Necrosis Factor / analysis* Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Systemic Inflammatory Response Syndrome / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Interleukin-6; 0/Receptors, Tumor Necrosis Factor; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 1995 Aug;172(2):607-8
[PMID:
7622919
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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