| Circulating interleukin-10: association with higher mortality in systolic heart failure patients with elevated tumor necrosis factor-alpha. | |
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MedLine Citation:
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PMID: 20684180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Interleukin-10 is an anti-inflammatory cytokine and consequently is considered by many to have a protective role in heart failure, as opposed to the notorious tumor necrosis factor-alpha. OBJECTIVES: To test the hypothesis of the possible beneficial impact of IL-10 on mortality in systolic heart failure patients in relation to their circulating TNFalpha levels. METHODS: We measured circulating levels of IL-10 and TNFalpha in 67 ambulatory systolic heart failure patients (age 65 +/- 13 years). RESULTS: Mortality was or tended to be higher in patients with higher levels (above median level) of circulating TNFalpha (9/23, 39% vs. 6/44, 14%; P = 0.02) or IL-10 (10/34, 30% vs. 5/33, 15%; P = 0.10). However, mortality was highest in the subset of patients with elevation of both markers above median (7/16, 44% vs. 8/51, 16%; P = 0.019). Elevation of both markers was associated with more than a threefold hazard ratio for mortality (HR 3.67, 95% confidence interval 1.14-11.78). CONCLUSIONS: Elevated circulating IL-10 levels in systolic heart failure patients do not have a protective counterbalance effect on mortality. Moreover, patients with elevated IL-10 and TNFalpha had significantly higher mortality, suggesting that the possible interaction in the complex inflammatory and anti-inflammatory network may need further study. |
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Authors:
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Offer Amir; Ori Rogowski; Miriam David; Nitza Lahat; Rafael Wolff; Basil S Lewis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Israel Medical Association journal : IMAJ Volume: 12 ISSN: 1565-1088 ISO Abbreviation: Isr. Med. Assoc. J. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930740 Medline TA: Isr Med Assoc J Country: Israel |
Other Details:
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Languages: eng Pagination: 158-62 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Heart Failure Center, Carmel, Israel. offeram@012.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Body Mass Index C-Reactive Protein / analysis Cause of Death Cholesterol / blood Chronic Disease Creatinine / blood Echocardiography Electrocardiography Exercise Test Female Follow-Up Studies Heart Failure, Systolic / blood*, ultrasonography Hemoglobins / analysis Humans Interleukin-10 / blood* Male Matrix Metalloproteinase 9 / blood Middle Aged Natriuretic Peptide, Brain / blood Peptide Fragments / blood Protein Precursors / blood Stroke Volume / physiology Troponin T / blood Tumor Necrosis Factor-alpha / blood* Ventricular Dysfunction, Left / blood, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Peptide Fragments; 0/Protein Precursors; 0/Troponin T; 0/Tumor Necrosis Factor-alpha; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 130068-27-8/Interleukin-10; 57-88-5/Cholesterol; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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