Document Detail


Circulating interleukin-10: association with higher mortality in systolic heart failure patients with elevated tumor necrosis factor-alpha.
MedLine Citation:
PMID:  20684180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Interleukin-10 is an anti-inflammatory cytokine and consequently is considered by many to have a protective role in heart failure, as opposed to the notorious tumor necrosis factor-alpha. OBJECTIVES: To test the hypothesis of the possible beneficial impact of IL-10 on mortality in systolic heart failure patients in relation to their circulating TNFalpha levels. METHODS: We measured circulating levels of IL-10 and TNFalpha in 67 ambulatory systolic heart failure patients (age 65 +/- 13 years). RESULTS: Mortality was or tended to be higher in patients with higher levels (above median level) of circulating TNFalpha (9/23, 39% vs. 6/44, 14%; P = 0.02) or IL-10 (10/34, 30% vs. 5/33, 15%; P = 0.10). However, mortality was highest in the subset of patients with elevation of both markers above median (7/16, 44% vs. 8/51, 16%; P = 0.019). Elevation of both markers was associated with more than a threefold hazard ratio for mortality (HR 3.67, 95% confidence interval 1.14-11.78). CONCLUSIONS: Elevated circulating IL-10 levels in systolic heart failure patients do not have a protective counterbalance effect on mortality. Moreover, patients with elevated IL-10 and TNFalpha had significantly higher mortality, suggesting that the possible interaction in the complex inflammatory and anti-inflammatory network may need further study.
Authors:
Offer Amir; Ori Rogowski; Miriam David; Nitza Lahat; Rafael Wolff; Basil S Lewis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  12     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Heart Failure Center, Carmel, Israel. offeram@012.net.il
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Mass Index
C-Reactive Protein / analysis
Cause of Death
Cholesterol / blood
Chronic Disease
Creatinine / blood
Echocardiography
Electrocardiography
Exercise Test
Female
Follow-Up Studies
Heart Failure, Systolic / blood*,  ultrasonography
Hemoglobins / analysis
Humans
Interleukin-10 / blood*
Male
Matrix Metalloproteinase 9 / blood
Middle Aged
Natriuretic Peptide, Brain / blood
Peptide Fragments / blood
Protein Precursors / blood
Stroke Volume / physiology
Troponin T / blood
Tumor Necrosis Factor-alpha / blood*
Ventricular Dysfunction, Left / blood,  ultrasonography
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Peptide Fragments; 0/Protein Precursors; 0/Troponin T; 0/Tumor Necrosis Factor-alpha; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 130068-27-8/Interleukin-10; 57-88-5/Cholesterol; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein; EC 3.4.24.35/Matrix Metalloproteinase 9

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