| Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong. | |
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MedLine Citation:
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PMID: 21606529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies identifying associations between influenza and acute cardiac events may have been confounded by climatic factors. Differing seasonal patterns of influenza activity in Hong Kong and England and Wales provide a natural experiment to examine associations with myocardial infarction (MI) independent of cold weather effects. METHODS: Weekly clinical and laboratory influenza surveillance data, environmental temperature and humidity data, and counts of MI-associated hospitalizations and deaths were obtained for England and Wales and for Hong Kong for the period 1998-2008. We used Poisson regression models that included environmental and seasonal variables to investigate the relationship between influenza and MI. RESULTS: There were ≥1.2 million MI-associated hospitalizations and 410,204 MI-associated deaths in England and Wales, with a marked peak in the winter season. In Hong Kong, the incidence of MI, on the basis of 65,108 hospitalizations and 18,780 deaths, had a large winter and smaller summer peak, mirroring patterns of influenza activity. There was strong evidence for a link between influenza and MI both in England and Wales, where 3.1%-3.4% of MI-associated deaths (P < .001) and 0.7%-1.2% of MI-associated hospitalizations (P < .001) were attributable to influenza, and in Hong Kong, where the corresponding figures were 3.9%-5.6% (P = .018) and 3.0%-3.3% (P = .002). CONCLUSIONS: Influenza was associated with an increase in MI-associated deaths and hospitalizations in 2 contrasting settings. |
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Authors:
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Charlotte Warren-Gash; Krishnan Bhaskaran; Andrew Hayward; Gabriel M Leung; Su-Vui Lo; Chit-Ming Wong; Joanna Ellis; Richard Pebody; Liam Smeeth; Benjamin J Cowling |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 203 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-24 Completed Date: 2011-07-28 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1710-8 Citation Subset: AIM; IM |
Affiliation:
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UCL Centre for Infectious Disease Epidemiology, Research Department of Infection & Population Health, Royal Free Hospital, Rowland Hill St, London NW3 2PF, UK. c.warrengash@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Climate* England / epidemiology Female Hong Kong / epidemiology Hospitalization / statistics & numerical data Humans Influenza A Virus, H3N2 Subtype* Influenza, Human / complications* Male Middle Aged Myocardial Infarction / complications*, epidemiology*, mortality Poisson Distribution Risk Factors Sentinel Surveillance Wales / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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1 U54GM088558/GM/NIGMS NIH HHS; U54 GM088558/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Comment In:
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J Infect Dis. 2012 May 15;205(10):1618-9
[PMID:
22474032
]
J Infect Dis. 2012 Jan 1;205(1):1-3 [PMID: 22170953 ] J Infect Dis. 2011 Jun 15;203(12):1701-4 [PMID: 21606526 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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