| Circulating bactericidal/permeability-increasing protein (BPI) is associated with serum lipids and endothelial function. | |
| | |
MedLine Citation:
|
PMID: 20174761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bactericidal/permeability-increasing protein (BPI), a major constituent of neutrophils that possesses anti-inflammatory properties, shows a structure similar to some proteins implicated in lipid metabolism. We evaluated circulating BPI as a biomarker of endothelial function and lipid metabolism. Circulating BPI concentrations (ELISA) and serum lipids were measured in 202 Caucasian non-smoking men. In a subgroup of 91 consecutive subjects brachial vascular reactivity (high resolution external ultrasound) was assessed. Plasma BPI concentrations were positively associated with total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) (r= 0.203, 0.204 and 0.18; all p<0.05, respectively). In a multiple linear regression analysis, BPI levels were independent contributors to the variance of HDL-C, total cholesterol and LDL-cholesterol after adjusting for age, body mass index and glucose tolerance status. Plasma BPI concentration correlated positively with endothelium-dependent vasodilatation (r=0.277; p<0.05) and HDL-C (r=0.36; p<0.05) in subjects with normal glucose tolerance. In conclusion, circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function. |
| | |
Authors:
|
Eduardo Esteve; Antoni Castro; Jose Maria Moreno; Joan Vendrell; Wifredo Ricart; José Manuel Fernández-Real |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-19 |
Journal Detail:
|
Title: Thrombosis and haemostasis Volume: 103 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-01 Completed Date: 2010-06-17 Revised Date: 2010-10-07 |
Medline Journal Info:
|
Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
|
Languages: eng Pagination: 780-7 Citation Subset: IM |
Affiliation:
|
Section of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomédica de Girona, Girona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antimicrobial Cationic Peptides / blood* Biological Markers / blood Blood Glucose / metabolism Blood Proteins Brachial Artery / physiology*, ultrasonography Endothelium, Vascular / physiology*, ultrasonography Enzyme-Linked Immunosorbent Assay European Continental Ancestry Group Glucose Tolerance Test Humans Linear Models Lipids / blood* Male Middle Aged Spain Vasodilation* |
| Chemical | |
Reg. No./Substance:
|
0/Antimicrobial Cationic Peptides; 0/Biological Markers; 0/Blood Glucose; 0/Blood Proteins; 0/Lipids; 0/bactericidal permeability increasing protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomoni...
Next Document: Age is a determinant factor for measures of concentration and effect in children requiring unfractio...