| Circulating RANKL/OPG in polymyalgia rheumatica. | |
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MedLine Citation:
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PMID: 17888221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate whether RANKL/OPG balance is modified in PMR patients, either in the active phase of the disease or during corticosteroid treatment. METHODS: Circulating levels of RANKL and OPG were assayed by enzyme-linked immunosorbent assay in PMR patients with active untreated disease and in patients treated by corticosteroids over a 12-month follow-up period. RESULTS: We found no statistically significant differences in circulating levels of OPG between PMR patients either in the active phase of the disease or during all follow-up period compared to normal controls. On the other hand, systemic production of sRANKL is increased and is not modulated by corticosteroid treatment. CONCLUSION: In PMR increased levels of sRANKL may be related to bone osteoporosis. Further investigations are necessary to evaluate the relationship between the RANK/RANKL/OPG system and bone turnover in PMR patients. |
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Authors:
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L Pulsatelli; P Dolzani; T Silvestri; L Boiardi; C Salvarani; P Macchioni; A Facchini; R Meliconi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 25 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2008-01-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: 621-3 Citation Subset: IM |
Affiliation:
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Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Aged Aged, 80 and over Enzyme-Linked Immunosorbent Assay Follow-Up Studies Humans Osteoprotegerin / blood* Polymyalgia Rheumatica / blood*, drug therapy RANK Ligand / blood* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Osteoprotegerin; 0/RANK Ligand |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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