Document Detail


Circulating RANKL/OPG in polymyalgia rheumatica.
MedLine Citation:
PMID:  17888221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate whether RANKL/OPG balance is modified in PMR patients, either in the active phase of the disease or during corticosteroid treatment. METHODS: Circulating levels of RANKL and OPG were assayed by enzyme-linked immunosorbent assay in PMR patients with active untreated disease and in patients treated by corticosteroids over a 12-month follow-up period. RESULTS: We found no statistically significant differences in circulating levels of OPG between PMR patients either in the active phase of the disease or during all follow-up period compared to normal controls. On the other hand, systemic production of sRANKL is increased and is not modulated by corticosteroid treatment. CONCLUSION: In PMR increased levels of sRANKL may be related to bone osteoporosis. Further investigations are necessary to evaluate the relationship between the RANK/RANKL/OPG system and bone turnover in PMR patients.
Authors:
L Pulsatelli; P Dolzani; T Silvestri; L Boiardi; C Salvarani; P Macchioni; A Facchini; R Meliconi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  25     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-09-24     Completed Date:  2008-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  621-3     Citation Subset:  IM    
Affiliation:
Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Aged
Aged, 80 and over
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Humans
Osteoprotegerin / blood*
Polymyalgia Rheumatica / blood*,  drug therapy
RANK Ligand / blood*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Osteoprotegerin; 0/RANK Ligand

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