Document Detail


Circulating immune complexes and rheumatoid factor in schistosomiasis and visceral leishmaniasis.
MedLine Citation:
PMID:  6824129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating immune complexes, measured by the C1q binding and Raji cell radioimmunoassays, were detected in 16 of 25 (64%) patients with schistosomiasis alone, in all 13 patients (100%) with schistosomiasis infection associated with prolonged bacteremia by salmonella organisms, and in 15 of 18 (83%) patients with visceral leishmaniasis. The C3 levels in the serum of patients with schistosomiasis, with and without prolonged salmonella bacteremia, were significantly lower in those with renal disease. Further, in patients with schistosomiasis alone, the absence of renal involvement was positively associated with C1q binding within the normal range (P = 0.015) and the presence of IgM rheumatoid factor in serum (P = 0.04). In six of eight patients with visceral leishmaniasis treated with a pentavalent antimonial, there was a fall in Raji cell binding, suggesting indirectly that the parasitic antigen may be involved in the pathogenic immune complexes in serum.
Authors:
E M Carvalho; B S Andrews; R Martinelli; M Dutra; H Rocha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  32     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antigen-Antibody Complex / analysis*
Child
Child, Preschool
Complement C3 / analysis
Female
Humans
Kidney Diseases / etiology
Leishmaniasis, Visceral / immunology*
Male
Middle Aged
Rheumatoid Factor / analysis*
Salmonella Infections / complications
Schistosomiasis / complications,  immunology*
Sepsis / complications
Grant Support
ID/Acronym/Agency:
A1 16282//PHS HHS; A1-16283//PHS HHS; AM 11766/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Complement C3; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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