Document Detail


Circulating immune complexes in the serum of diabetes mellitus in childhood by a modified 125I-C1q binding test.
MedLine Citation:
PMID:  316767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 125I-C1q binding test for the detection of soluble immune complexes in native unheated human serum was applied to the study of sera from 52 patients with diabetes mellitus in childhood. This radiolabeled C1q binding test is more sensitive and reproducible among the various methods proposed for the detection of immune complexes. The 125I-C1q binding activity in 52 sera from diabetes mellitus in childhood was 9.47 +/- 0.36% compared to 6.94 +/- 0.74% in normal controls. 125I-C1q binding values in diabetes mellitus in childhood were significantly higher than normal controls. Slight high values were seen in 3 patients with positive anti-DNA-antibodies in diabetes mellitus in childhood. 125I-C1q binding was not significantly increased in patients with positive antithyroid antibodies and insulin antibodies. There was no significant correlation between the duration of diabetes and 125I-C1q binding activity.
Authors:
K Nagaoka; Y Chinen; T Takegami; N Nabeya; T Sakurami; H Imura; S Kuno; K Tasaka; Y Hamajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinologia japonica     Volume:  26     ISSN:  0013-7219     ISO Abbreviation:  Endocrinol. Jpn.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-04-23     Completed Date:  1980-04-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376546     Medline TA:  Endocrinol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  527-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Antinuclear / analysis
Antigen-Antibody Complex*
Binding Sites, Antibody
Child
Child, Preschool
Complement Activating Enzymes / diagnostic use
Complement C1 / immunology
Diabetes Mellitus, Type 1 / immunology*
Female
Humans
Infant
Insulin Antibodies / analysis
Iodine Radioisotopes / diagnostic use
Male
Thyroid Gland / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antigen-Antibody Complex; 0/Binding Sites, Antibody; 0/Complement C1; 0/Insulin Antibodies; 0/Iodine Radioisotopes; EC 3.-/Complement Activating Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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