Document Detail


Circulating immune complexes in patients with nasopharyngeal carcinoma.
MedLine Citation:
PMID:  1689798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of the serum of patients with nasopharyngeal carcinoma (NPC) demonstrate increased levels of immunoglobulins (Igs), Epstein-Barr virus (EBV) antibodies, and specific immunosuppressive acute-phase proteins (haptoglobin, alpha 1-acid glycoprotein). Recent correlations of the levels of acute-phase and immune-reactive proteins with tumor extent, immune reactivity, and circulating immune complex (CIC) levels in patients with head and neck squamous carcinoma prompted an investigation of the relationship of CICs to those protein factors characteristically altered in the serum of patients with NPC. In 70 untreated NPC patients and 21 normal participants, levels of CIC, Igs, immune-reactive proteins, and EBV antibody titers were measured and correlations with tumor extent and clinical stage determined. In patients with advanced tumors (stages III and IV), levels of CIC, immunoglobulin A (IgA), immunoglobulin M (IgM), and acute-phase proteins (haptoglobin, alpha 1-acid glycoprotein, alpha 1-antitrypsin) were significantly increased compared to stage I, stage II patients, or normals. In patients with elevated CIC levels, levels of IgA and IgM were significantly increased compared to normals or patients with normal CIC levels. Uniquely, serum IgA levels correlated directly with CIC levels among patients but not controls. EBV antibody titers were increased in the NPC patients and were not significantly related to tumor extent or CIC levels. The immunosuppressive properties of CICs might account, in part, for the immune suppression previously reported in patients with NPC. Thus, the increased levels of CICs demonstrated in these patients provide a rationale for evaluating the effects of removing CICs, since such therapeutic manipulations have been associated with tumor regressions in patients with other tumor types.
Authors:
G T Wolf; R A Wolfe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  100     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-09     Completed Date:  1990-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  302-8     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor 48109-0312.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis
Adolescent
Adult
Aged
Antibodies, Viral / analysis
Antigen-Antibody Complex*
Carcinoma / blood,  immunology*,  microbiology
Herpesvirus 4, Human / immunology
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Middle Aged
Nasopharyngeal Neoplasms / blood,  immunology*,  microbiology
Neoplasm Staging
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Antibodies, Viral; 0/Antigen-Antibody Complex; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M

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