Document Detail


Circulating immune complexes in multiple sclerosis. Relation to clinical and biological parameters.
MedLine Citation:
PMID:  687746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating immune complexes were looked for on 38 clinically definite MS (multiple sclerosis) patients compared to 35 other neurological patients and 26 healthy subjects. 29% of the MS sera and 8.6% of the other neurological sera were positive, whereas none of the control sera were positive. These differences are significant. Clinical status was analysed as regards the age at onset, the duration and course of the disease, the disability of the patients and the treatment they received. CSF (cerebrospinal fluid) parameters studied were pleocytosis, concentration of total protein, electrophoresis. The results suggest that IC (immune complex) are more frequent during the first 10 years of the MS disease, in patients with blood-brain barrier damage and in patients without oligoclonal IgG.
Authors:
P Davous; C M Jacque; L Grangeot-Keros; R Marteau; N Baumann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine / [publiée pour l'A.A.I.C.I.G.]     Volume:  29     ISSN:  0300-0893     ISO Abbreviation:  Biomedicine     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361342     Medline TA:  Biomedicine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  103-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Antigen-Antibody Complex*
Cerebrospinal Fluid / analysis,  cytology
Female
Humans
Immunoglobulin G / analysis
Lymphocytes
Male
Multiple Sclerosis / cerebrospinal fluid,  immunology*
Time Factors
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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