Document Detail

Circulating immune complexes in diabetics: the influence of sex, age, duration of disease and type of treatment.
MedLine Citation:
PMID:  6348294     Owner:  NLM     Status:  MEDLINE    
The influence of sex, age, duration of diabetes and type of antidiabetic treatment on soluble immune complexes levels was investigated in the sera of 276 randomly selected diabetics. Immune complexes were detected by the solid phase C1q binding test. The prevalence of immune complexes was significantly higher in insulin treated than in non-insulin treated diabetics. Within the insulin treated group, the prevalence in diabetics of 11-20 yr duration was significantly higher than in the remainder. No difference in immune complexes levels was found between males and females. The age of the patients did not have any correlation with the levels of immune complexes. These findings suggest that some of the immune complexes detected in randomly selected diabetics are related to insulin treatment, reflecting either differences in the type of diabetes or the effects of heterologous insulin.
U Di Mario; W J Irvine; K Guy; D Q Borsey; M Iavicoli; L Ventriglia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  11     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antigen-Antibody Complex / analysis*
Child, Preschool
Diabetes Mellitus / drug therapy,  immunology*
Infant, Newborn
Insulin / therapeutic use
Middle Aged
Sex Factors
Time Factors
Reg. No./Substance:
0/Antigen-Antibody Complex; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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