Document Detail


Circulating heart-type Fatty Acid binding protein levels predict the occurrence of appropriate shocks and cardiac death in patients with implantable cardioverter-defibrillators.
MedLine Citation:
PMID:  22748489     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The association between ongoing myocardial damage and outcomes in patients who have received an implantable cardioverter-defibrillator (ICD) is unclear.
METHODS AND RESULTS: Consecutive patients with cardiomyopathy, who had received an ICD (n = 107, mean age 65 ± 11 years), were prospectively enrolled. Myocardial membrane injury (heart-type fatty acid binding protein [H-FABP] >4.3 ng/mL) and myofibrillar injury (troponin T >0.01 ng/mL) were defined using receiver operating characteristic curves. Patients were followed for a median of 33.6 months, to an end point of appropriate ICD shock or cardiac death. Myocardial membrane injury (45%) and myofibrillar injury (41%) were equally prevalent among patients with cardiomyopathy who had received ICDs. Appropriate ICD shocks or cardiac death occurred in 31% and 15% of patients, respectively. Multivariate Cox regression analysis showed that serum H-FABP levels >4.3 ng/mL, but not troponin T levels, were a significant independent prognostic factor for cardiac events (hazard ratio 5.502, 95% confidence interval 1.705-17.75, P = .004). Subgroup analysis revealed that measuring H-FABP levels was valuable for anticipating event-free survival among patients with ICDs who were receiving amiodarone. High H-FABP levels also predicted subsequent outcomes in patients who had received ICDs for primary or secondary prevention.
CONCLUSION: Evaluating myocardial damage using H-FABP may be a promising tool for predicting outcomes in patients with cardiomyopathy who have received ICDs.
Authors:
Hyuma Daidoji; Takanori Arimoto; Joji Nitobe; Harutoshi Tamura; Daisuke Kutsuzawa; Daisuke Ishigaki; Mitsunori Ishino; Hiroki Takahashi; Tetsuro Shishido; Takehiko Miyashita; Takuya Miyamoto; Tetsu Watanabe; Isao Kubota
Related Documents :
21949529 - Thrombophilia, left ventricular dysfunction and intracardiac thrombi in children.
2889599 - The effects of beta-adrenergic blocking agents on atherosclerosis and its complications.
15212609 - Candesartan for the treatment of hypertension and heart failure.
22917729 - Culprit only or multivessel percutaneous coronary interventions in patients with st-seg...
22418249 - An update on diastolic dysfunction.
22511269 - Revascularization of unprotected left main coronary artery disease: strategy selection ...
3265059 - Aortic intimal lipid content and serum lipoproteins in patients undergoing coronary by-...
6640559 - Comparative study of electrophysiological and holter monitoring data in estimating sino...
1733309 - Favorable effects of hyperosmotic reperfusion on myocardial edema and infarct size.
Publication Detail:
Type:  Journal Article     Date:  2012-05-09
Journal Detail:
Title:  Journal of cardiac failure     Volume:  18     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cerebral blood flow as a marker for recovery of left ventricular systolic dysfunction in patients wi...
Next Document:  Plasma pro-B-type natriuretic Peptide testing as a screening method for hypertrophic cardiomyopathy.