Document Detail

Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women.
MedLine Citation:
PMID:  11735097     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis is increasingly recognized as an inflammatory disease. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a proinflammatory cytokine, recently implicated as a prominent component of the regulatory network involved in atherogenesis. We aimed to study the relationship between circulating GM-CSF levels and serum fatty acid (FA) composition in 78 healthy subjects. The latter was analyzed by gas-liquid chromatography and GM-CSF by a high-sensitivity commercial enzyme-linked immunosorbent assay (ELISA). Among women (n = 40), serum GM-CSF levels were found to be positively associated with the proportion of palmitic acid (C16:0) and negatively with linoleic acid (C18:2omega-6), docosahexaenoic acid (DHA, C22:6omega-3), and the proportion of total essential FA. After excluding smoking women (n = 6), the associations among GM-CSF and serum linoleic acid concentration (r = -0.49, P =.003), arachidonic acid (r = -0.52, P =.001), and DHA (r = -0.34, P =.04) were strengthened. The ratio of palmitic to linoleic and DHA acids was the single best predictor of serum GM-CSF in all subjects. Together with arachidonic acid, it contributed to 22% of the GM-CSF variance in women, after taking into account the effects of age, body mass index (BMI), blood pressure, and smoking status. None of these associations were observed among men. In conclusion, serum FA composition is associated with circulating GM-CSF specifically in women. As human arterial and venous smooth muscle cells release GM-CSF, and treatment of endothelial cells with oxidized low-density lipoproteins results in a rapid expression of GM-CSF, the mechanisms involved in these associations and the sex-linked differences should be further explored.
J M Fernández-Real; M Vayreda; R Casamitjana; F Gonzalez-Huix; W Ricart
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  50     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-05     Completed Date:  2002-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1479-83     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company
Unitat de Diabetologia, Endocrinologia i Nutrició, and Department of Gastroenterology, University Hospital of Girona Dr Josep Trueta, Girona, Spain.
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MeSH Terms
Arteriosclerosis / blood
Blood Pressure
Body Mass Index
Docosahexaenoic Acids / blood
Enzyme-Linked Immunosorbent Assay
Fatty Acids / blood*
Fatty Acids, Unsaturated / blood
Granulocyte-Macrophage Colony-Stimulating Factor / blood*
Linear Models
Linoleic Acid / blood
Middle Aged
Palmitic Acid / blood
Reference Values
Sex Characteristics
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 57-10-3/Palmitic Acid; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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