| Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | |
| | |
MedLine Citation:
|
PMID: 11735097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Atherosclerosis is increasingly recognized as an inflammatory disease. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a proinflammatory cytokine, recently implicated as a prominent component of the regulatory network involved in atherogenesis. We aimed to study the relationship between circulating GM-CSF levels and serum fatty acid (FA) composition in 78 healthy subjects. The latter was analyzed by gas-liquid chromatography and GM-CSF by a high-sensitivity commercial enzyme-linked immunosorbent assay (ELISA). Among women (n = 40), serum GM-CSF levels were found to be positively associated with the proportion of palmitic acid (C16:0) and negatively with linoleic acid (C18:2omega-6), docosahexaenoic acid (DHA, C22:6omega-3), and the proportion of total essential FA. After excluding smoking women (n = 6), the associations among GM-CSF and serum linoleic acid concentration (r = -0.49, P =.003), arachidonic acid (r = -0.52, P =.001), and DHA (r = -0.34, P =.04) were strengthened. The ratio of palmitic to linoleic and DHA acids was the single best predictor of serum GM-CSF in all subjects. Together with arachidonic acid, it contributed to 22% of the GM-CSF variance in women, after taking into account the effects of age, body mass index (BMI), blood pressure, and smoking status. None of these associations were observed among men. In conclusion, serum FA composition is associated with circulating GM-CSF specifically in women. As human arterial and venous smooth muscle cells release GM-CSF, and treatment of endothelial cells with oxidized low-density lipoproteins results in a rapid expression of GM-CSF, the mechanisms involved in these associations and the sex-linked differences should be further explored. |
| | |
Authors:
|
J M Fernández-Real; M Vayreda; R Casamitjana; F Gonzalez-Huix; W Ricart |
Related Documents
:
|
2413327 - Correlations between aminergic metabolites simultaneously obtained from human csf and b... 3258017 - Histamine metabolites in cerebrospinal fluid of the rhesus monkey (macaca mulatta): cis... 2409957 - Biogenic amine/metabolite response during in-flight emergencies. 7694027 - Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: relationship w... 11014597 - Bridging the gap: a set of selective 1h-15n-correlations to link sequential neighbors o... 17394337 - In vitro and in vivo stability of caffeic acid phenethyl ester, a bioactive compound of... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 50 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2001 Dec |
Date Detail:
|
Created Date: 2001-12-05 Completed Date: 2002-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 1479-83 Citation Subset: IM |
Copyright Information:
|
Copyright 2001 by W.B. Saunders Company |
Affiliation:
|
Unitat de Diabetologia, Endocrinologia i Nutrició, and Department of Gastroenterology, University Hospital of Girona Dr Josep Trueta, Girona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arteriosclerosis / blood Blood Pressure Body Mass Index Docosahexaenoic Acids / blood Enzyme-Linked Immunosorbent Assay Fatty Acids / blood* Fatty Acids, Unsaturated / blood Female Granulocyte-Macrophage Colony-Stimulating Factor / blood* Humans Linear Models Linoleic Acid / blood Male Middle Aged Palmitic Acid / blood Reference Values Sex Characteristics Smoking |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 57-10-3/Palmitic Acid; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients.
Next Document: Exercise-induced oxidative stress in older adults as measured by antipyrine oxidation.