| Circulating ghrelin levels after food intake during different phases of the migrating motor complex in man. | |
| | |
MedLine Citation:
|
PMID: 16796608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The timing of the migrating motor complexes (MMC) at food intake may influence gastric emptying and release of regulatory hormones. This report studies the relationships between phases I (motor quiescence) and II (intermediate frequency contractions) of MMC and prandial gut hormone response. MATERIALS AND METHODS: Seven fasting volunteers ingested a meal during phase I or II of MMC verified by manometry, using paracetamol as a marker for gastric emptying. Blood was sampled before, during and 210 min after food intake for analysis of ghrelin, motilin, insulin and paracetamol. RESULTS: The basal level of ghrelin during phase I was 127.5 +/- 25.4 pmol L(-1) and during phase II was 132.4 +/- 24.8 pmol L(-1). After food intake during phase I, ghrelin fell to 77.2 +/- 10 pmol L(-1); in phase II it fell to 82.7 +/- 17.8 pmol L(-1) within 60 min and returned to baseline levels after 120 min. Baseline levels of motilin were 16 +/- 2 pmol L(-1) and 18 +/- 3 pmol L(-1) during phases I and II, respectively. After food, motilin decreased to 8.5 +/- 0.7 pmol L(-1) and 8.7 +/- 1.0 pmol L(-1) within 60 min and returned to baseline after 90 min. Insulin levels in phases I and II were 8.1 +/- 1.2 mU L(-1) and 8.6 +/- 0.7 mU L(-1), respectively, reaching 138.9 +/- 35.6 mU L(-1) and 167.4 +/- 30.0 mU L(-1) at 45 min postprandially. CONCLUSIONS: The nutritional status of the gastrointestinal tract at food intake had only a limited impact on plasma ghrelin. After food intake, plasma ghrelin drops, similar to motilin, and resumes preprandial levels within 120 min. |
| | |
Authors:
|
P T Schmidt; M Degerblad; E Lindström; M Sundqvist; E Näslund; P G Gillberg; E Husebye; E Theodorsson; P M Hellström |
Related Documents
:
|
8518948 - Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced... 15064138 - Metabolic fuels, neuropeptide y, and estrous behavior in syrian hamsters. 1923938 - Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide y in the hypot... 8995788 - Trypsin and aminopeptidase gene expression is affected by age and food composition in a... 21477628 - Does meal duration predict amount consumed in lone diners? an evaluation of the time-ex... 14710598 - Dioxin, dibenzofuran, and polychlorinated biphenyl (pcb) levels in food from agent oran... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of clinical investigation Volume: 36 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 2006 Jul |
Date Detail:
|
Created Date: 2006-06-26 Completed Date: 2006-11-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: England |
Other Details:
|
Languages: eng Pagination: 503-8 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology and Hepatology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. peter.thelin.schmidt@medks.ki.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetaminophen
/
blood Adult Analgesics, Non-Narcotic / blood Eating / physiology* Gastric Emptying / physiology Gastrointestinal Agents / blood Ghrelin Humans Insulin / blood Male Motilin / blood Myoelectric Complex, Migrating / physiology* Peptide Hormones / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Non-Narcotic; 0/Gastrointestinal Agents; 0/Ghrelin; 0/Peptide Hormones; 103-90-2/Acetaminophen; 11061-68-0/Insulin; 52906-92-0/Motilin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Infection induced inflammation is associated with erectile dysfunction in men with diabetes.
Next Document: Sounding airflow enhances aerosol delivery into the paranasal sinuses.