| Circulating free fetal nucleic acids in maternal plasma and preeclampsia. | |
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MedLine Citation:
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PMID: 20129741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although preeclampsia represents a major threat for many pregnant women, the pathogenesis of this complication is far from being clear. Recent studies suggest that preeclampsia is an autoimmune disorder. Auto-antibodies against angiotensin receptor might explain some of the pathologic findings associated with preeclampsia. However, the origin of the autoimmune reaction is unknown. Here we hypothesize that circulating fetal RNA in maternal plasma might transfect maternal cells. Expression of fetal specific sequences could lead to an immune reaction breaking the immune tolerance against some antigens. Male fetus bearing pregnancies could be at higher risk of preeclampsia due to expression of Y-specific transcripts. This hypothesis is testable by analyzing antibodies and T-lymphocytes of pregnant women with male and female fetuses. |
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Authors:
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Barbora Vlková; Tomás Szemes; Gabriel Minárik; Ján Turna; Peter Celec |
Publication Detail:
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Type: Journal Article Date: 2010-02-02 |
Journal Detail:
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Title: Medical hypotheses Volume: 74 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 1030-2 Citation Subset: IM |
Affiliation:
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Geneton Inc., Cabanova 14, Bratislava, Slovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity Chromosomes, Human, Y / genetics Female Fetal Blood / metabolism* Humans Immune Tolerance Immunity, Cellular Male Maternal-Fetal Exchange / genetics, immunology Models, Biological Nucleic Acids / blood*, genetics Pre-Eclampsia / blood*, etiology, immunology Pregnancy Sex Characteristics Transfection |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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