Document Detail


Circulating filarial antigens for monitoring the efficacy of ivermectin in treatment of filariasis.
MedLine Citation:
PMID:  11478456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy-three asymptomatic bancroftian filariasis patients with positive microfilaria in their blood films were included. The patients were randomly divided into 2 groups: ivermectin group (50 cases) given 2 doses each of 100 ug/kg body weight, 3 months apart, and 23 cases had 2 doses of placebo. The study was run blindly for one year. The initial mean microfilaria (MF) count was 111/ml. At 3 months after ivermectin therapy, mean MF became 7.8/ml and 24% of ivermectin treated cases had no detectable MF (P <0.05). At 6, 9 and 12 months, the mean MF count became 4.1, 6.5 and 11/ml with amicrofilaria in 54%, 42% and 40% of treated cases respectively (P <0.05). On the other hand, no statistically significant change in the mean MF count in placebo group was detected. The routine laboratory investigations were unchanged or slightly improved at 3 and 6 months. Side effects after the first dose of ivermectin were mild fever in 16% and weakness in 20%. None was recorded after the second dose. Circulating filarial antigens could be detected in 66% of cases before treatment, as all cases with high microfilaremia had positive antigenemia. The mean antigen level started to decline significantly after 9 months post treatment. At the end of the study (one-year), all negative microfilaremic cases had negative antigen levels, indicating that detection of antigen in-patients sera is a very good indicator of cure and efficacy of the drug.
Authors:
M M Hassan; M A Bahgat; A E Ali; A Saleh; O K El-Shafae; M M Abdel-Ghaffar; N M Mowafy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Egyptian Society of Parasitology     Volume:  31     ISSN:  1110-0583     ISO Abbreviation:  J Egypt Soc Parasitol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-31     Completed Date:  2001-10-04     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8102141     Medline TA:  J Egypt Soc Parasitol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  575-81     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Faculty of Medicine, Zagazig University, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anthelmintics / therapeutic use*
Antigens, Helminth / blood*
Biological Markers / blood
Female
Filariasis / drug therapy*,  immunology
Humans
Ivermectin / therapeutic use*
Male
Prognosis
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Antigens, Helminth; 0/Biological Markers; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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