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Circulating fibroblast growth factors as metabolic regulators-a critical appraisal.
MedLine Citation:
PMID:  23217254     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that-although a number of questions remain-circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.
Authors:
Bo Angelin; Tobias E Larsson; Mats Rudling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  16     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-705     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences NOVUM, Karolinska Institute at Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden. Electronic address: bo.angelin@ki.se.
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