Document Detail

Circulating endothelial progenitor cells in premature infants: is there an association with premature birth complications?
MedLine Citation:
PMID:  22752779     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The most common morbidities in preterm infants are associated with vascular pathology. Endothelial progenitor cells (EPCs) have been implicated in repair of the vasculature, but their role in the pathogenesis of prematurity complications is not clear.
OBJECTIVES: We prospectively investigated an association between the number of EPCs circulating in blood during delivery as well as 2 and 6 weeks afterwards, the level of growth factors regulating their migration/homing, and the incidence of premature birth complications.
PATIENTS AND METHODS: The study groups consisted of 90 preterm and 52 full-term infants. Early-EPCs (CD133+CD34+CD144+) and late-EPCs (CD133-CD34+CD144+) were analysed in cord blood (CB) and peripheral blood (PB).
RESULTS: We found higher early- and late-EPC counts in the CB of premature infants compared with full-term babies. The number of circulating early- and late-EPCs was inversely associated with the Apgar score of preterm infants. A positive association between the early-EPC count and the risk of respiratory distress syndrome, retinopathy of prematurity, bronchopulmonary dysplasia, and infections was found. Nevertheless, multivariate analysis revealed that a higher number of EPCs was not an independent predictor of prematurity complications, which were directly related to lower gestational age. The EPC count in full-term infants maintained a constant, relatively low level over the 6-week follow-up, whereas the EPC population in preterm infants gradually decreased during this period. Furthermore, the number of CB late-EPCs in preterm infants positively correlated with VEGF concentration.
CONCLUSIONS: EPCs may play a considerable role in vascular development in preterm infants.
Krzysztof Safranow; Maciej Kotowski; Joanna Lewandowska; Anna Machalińska; Violetta Dziedziejko; Ryszard Czajka; Zbigniew Celewicz; Jacek Rudnicki; Bogusław Machaliński
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-22
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  40     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-23     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  455-62     Citation Subset:  IM    
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MeSH Terms
Apgar Score
Bronchopulmonary Dysplasia / blood
Cell Count
Endothelial Cells / cytology*,  physiology
Fetal Blood / cytology
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood*,  epidemiology
Intercellular Signaling Peptides and Proteins / blood
Neovascularization, Physiologic / physiology
Prospective Studies
Respiratory Distress Syndrome, Newborn / blood
Retinopathy of Prematurity / blood
Risk Factors
Stem Cells / cytology*,  physiology
Vascular Endothelial Growth Factor A / blood
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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