Document Detail


Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation.
MedLine Citation:
PMID:  15191769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Endothelial progenitor cells (EPC) are present in peripheral blood and can develop a functional endothelial phenotype. The number and function of circulating EPCs are altered in atherosclerosis, diabetes, and after myocardial infarction and EPCs have been shown to promote postnatal angiogenesis and vasculogenesis. We investigated the number and adhesive properties of EPCs from patients with unstable angina and no evidence of cardiac necrosis. METHODS AND RESULTS: Patients were selected with unstable angina (n=29) and no evidence of cardiac necrosis, and controls with stable angina (n=12) and atherosclerotic risk factors, medication use, and coronary vessel involvement similar to patients. Circulating EPC numbers were determined by colony-forming unit assay and their adhesive properties were evaluated by EPC capacity to bind immobilised fibronectin. High-sensitivity C-reactive protein (hsCRP) was determined in all patients. Circulating EPCs were significantly increased in patients with unstable as compared with stable angina (24.5+/-2.6 vs. 13.3+/-2.9, respectively). Seven unstable angina patients followed up for 3 months after clinical stabilisation exhibited a reduction of close to 50% in circulating EPC numbers. The adhesive capacity of EPCs from patients with unstable and stable angina did not differ. A positive correlation was found between systemic CRP levels and circulating EPC numbers, but not their adhesive capacity. CONCLUSION: Patients with unstable angina and no evidence of cardiac necrosis exhibited increased circulating EPCs. Systemic inflammation, in addition to recognised growth factors, could play a role in the peripheral mobilisation of EPCs in patients with anginal syndromes.
Authors:
Jacob George; Emil Goldstein; Soulico Abashidze; Varda Deutsch; Haim Shmilovich; Ariel Finkelstein; Itzhak Herz; Hylton Miller; Gad Keren
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  25     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-11     Completed Date:  2004-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1003-8     Citation Subset:  IM    
Affiliation:
The Department of Cardiology and the Haematology Institute, Tel Aviv Sourasky Medical Center and The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. jacobg@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Angina, Unstable / blood,  pathology*
Cell Adhesion / physiology
Endothelial Cells / pathology*
Endothelium, Vascular / pathology
Female
Humans
Male
Middle Aged
Stem Cells / pathology*
Vascular Endothelial Growth Factor A / blood
Vasculitis / pathology*
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A
Comments/Corrections
Comment In:
Eur Heart J. 2004 Jun;25(12):999-1000   [PMID:  15191767 ]

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