Document Detail

Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  16836609     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Endothelial progenitor cell (EPC), which mediates neovascularization of uterine endometrium may be involved in the neovascularization in the utero-placental circulation. We evaluated whether EPC proliferation in pre-eclampsia (PE) differed from that in normal pregnancy. METHOD OF STUDY: EPC number in peripheral blood (20 non-pregnancy, 36 normal pregnancy, 10 PE) was measured using flow cytometry. Peripheral blood mononuclear cell was cultured for 7 days and EPC proliferation was assessed based on detection of the uptake of acetylated low-density lipoprotein and lectin. Furthermore, the proliferative activity induced by angiotensin II (Ang II) and tumor necrosis factor-alpha (TNF-alpha) was measured by BrdU assay. RESULTS: EPC number in peripheral blood did not differ significantly between PE and normal pregnancy; however, EPC proliferation was significantly increased in PE. Furthermore, Ang II and TNF-alpha induced the proliferation of EPC derived from patients with PE. CONCLUSIONS: In PE, some factors including Ang II and TNF-alpha stimulated EPC proliferation; however, the impairment of EPC mobilization into systemic circulation by serum factors may contribute to insufficient regeneration of EC in disturbed utero-placental circulation of PE.
Keiichi Matsubara; Emiko Abe; Yuko Matsubara; Kenji Kameda; Masaharu Ito
Related Documents :
15726229 - Periodontal disease -- the emergence of a risk for systemic conditions: pre-term low bi...
10492869 - Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-...
7877539 - Maternal and neonatal outcome of patients classified according to the australasian soci...
10796269 - Reduced salt intake compared to normal dietary salt, or high intake, in pregnancy.
21729009 - High positive antibody titers and adverse pregnancy outcome in women with antiphospholi...
11794659 - Properties of flocs produced by water treatment coagulants.
10079489 - Can transvaginal fetal biometry be considered a useful tool for early detection of skel...
3720979 - Intrauterine inseminations with washed human spermatozoa.
7363909 - Intrauterine growth of twins. a retrospective analysis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  56     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-13     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Ehime University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Proliferation*
Cells, Cultured
Endothelial Cells / cytology*,  immunology
Leukocytes, Mononuclear / cytology*,  immunology
Pre-Eclampsia / blood*,  immunology
Pregnancy / blood*
Stem Cells / cytology*,  immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Psychosis or temporal lobotomy: SPECT findings in a paraplegic patient with chronic mental illness.
Next Document:  Vaginal nitric oxide in pregnant women with bacterial vaginosis.