Document Detail


Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  16836609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: Endothelial progenitor cell (EPC), which mediates neovascularization of uterine endometrium may be involved in the neovascularization in the utero-placental circulation. We evaluated whether EPC proliferation in pre-eclampsia (PE) differed from that in normal pregnancy. METHOD OF STUDY: EPC number in peripheral blood (20 non-pregnancy, 36 normal pregnancy, 10 PE) was measured using flow cytometry. Peripheral blood mononuclear cell was cultured for 7 days and EPC proliferation was assessed based on detection of the uptake of acetylated low-density lipoprotein and lectin. Furthermore, the proliferative activity induced by angiotensin II (Ang II) and tumor necrosis factor-alpha (TNF-alpha) was measured by BrdU assay. RESULTS: EPC number in peripheral blood did not differ significantly between PE and normal pregnancy; however, EPC proliferation was significantly increased in PE. Furthermore, Ang II and TNF-alpha induced the proliferation of EPC derived from patients with PE. CONCLUSIONS: In PE, some factors including Ang II and TNF-alpha stimulated EPC proliferation; however, the impairment of EPC mobilization into systemic circulation by serum factors may contribute to insufficient regeneration of EC in disturbed utero-placental circulation of PE.
Authors:
Keiichi Matsubara; Emiko Abe; Yuko Matsubara; Kenji Kameda; Masaharu Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  56     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-13     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Ehime University School of Medicine, Japan. keiichi@m.ehime-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Proliferation*
Cells, Cultured
Endothelial Cells / cytology*,  immunology
Female
Humans
Leukocytes, Mononuclear / cytology*,  immunology
Pre-Eclampsia / blood*,  immunology
Pregnancy / blood*
Stem Cells / cytology*,  immunology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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