| Circulating endothelial progenitor cells during normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 16836609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: Endothelial progenitor cell (EPC), which mediates neovascularization of uterine endometrium may be involved in the neovascularization in the utero-placental circulation. We evaluated whether EPC proliferation in pre-eclampsia (PE) differed from that in normal pregnancy. METHOD OF STUDY: EPC number in peripheral blood (20 non-pregnancy, 36 normal pregnancy, 10 PE) was measured using flow cytometry. Peripheral blood mononuclear cell was cultured for 7 days and EPC proliferation was assessed based on detection of the uptake of acetylated low-density lipoprotein and lectin. Furthermore, the proliferative activity induced by angiotensin II (Ang II) and tumor necrosis factor-alpha (TNF-alpha) was measured by BrdU assay. RESULTS: EPC number in peripheral blood did not differ significantly between PE and normal pregnancy; however, EPC proliferation was significantly increased in PE. Furthermore, Ang II and TNF-alpha induced the proliferation of EPC derived from patients with PE. CONCLUSIONS: In PE, some factors including Ang II and TNF-alpha stimulated EPC proliferation; however, the impairment of EPC mobilization into systemic circulation by serum factors may contribute to insufficient regeneration of EC in disturbed utero-placental circulation of PE. |
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Authors:
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Keiichi Matsubara; Emiko Abe; Yuko Matsubara; Kenji Kameda; Masaharu Ito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 56 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-13 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 79-85 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Ehime University School of Medicine, Japan. keiichi@m.ehime-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Proliferation* Cells, Cultured Endothelial Cells / cytology*, immunology Female Humans Leukocytes, Mononuclear / cytology*, immunology Pre-Eclampsia / blood*, immunology Pregnancy / blood* Stem Cells / cytology*, immunology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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