Document Detail

Circulating endothelial progenitor cells decreased in patients with sclerodermatous chronic graft-versus-host disease.
MedLine Citation:
PMID:  18342785     Owner:  NLM     Status:  MEDLINE    
Chronic graft-versus-host disease (cGVHD) is a common late complication of allogeneic stem cell transplantation (allo-SCT). Some cGVHD patients develop skin lesions, and the skin lesions in sclerodermatous cGVHD (s-cGVHD) patients resemble those in progressive systemic sclerosis (PSS), which is characterized by impaired production of circulating endothelial progenitor cells (EPCs). We investigated, retrospectively, whether low EPC production may promote the development of sclerodermatous lesions in cGVHD. Peripheral blood (PB) was obtained from 14 healthy volunteers and 27 allo-SCT patients. Five patients developed s-cGVHD. CD34(+) cells were purified by using the magnetic cell-sorting separation system, and the CD34(+)/CD133(+)/vascular endothelial growth factor (VEGF) receptor-2(+) EPCs were quantified. The endothelial cell colony-formation potential was evaluated. Serum VEGF and basic fibroblast growth factor (b-FGF) concentrations were measured by ELISA. The s-cGVHD patients had significantly lower median circulating EPCs frequencies than non-s-cGVHD patients or control (145 of 20 mL [interquartial range-IQR 107-193] versus 1083.5 [IQR 669.3-2151]; P = .0023, and versus 1530.5 [IQR 961.3-2158]; P = .0012, respectively). They also had impaired median endothelial-forming ability compared to non-s-cGVHD patients or controls (3.8 [IQR 1.0-4.3] versus 12.8 [IQR 8.8-28.8], and versus 26.4 [IQR 23.6-30.6], respectively; P = .0012). Their VEGF and b-FGF serum levels were also higher than in controls. In conclusion, s-cGVHD patients show findings consistent with those seen in PSS with impaired vasculogenesis that may limit blood perfusion and may contribute to the development of sclerodermatous lesions.
Kazuho Shimura; Eishi Ashihara; Chihiro Shimazaki; Shinsaku Matsunaga; Kyoko Taniguchi; Hitoji Uchiyama; Yosuke Matsumoto; Shinya Kimura; Hiroaki Matsubara; Masafumi Taniwaki; Taira Maekawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation     Volume:  14     ISSN:  1523-6536     ISO Abbreviation:  Biol. Blood Marrow Transplant.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600628     Medline TA:  Biol Blood Marrow Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-37     Citation Subset:  IM    
Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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MeSH Terms
Acute Disease
Antigens, CD / blood
Antigens, CD34 / blood
Chronic Disease
Colony-Forming Units Assay
Endothelium, Vascular / immunology,  pathology*
Graft vs Host Disease / blood,  epidemiology,  immunology,  pathology*
Middle Aged
Reference Values
Scleroderma, Limited / blood,  epidemiology,  immunology,  pathology*
Stem Cells / pathology*
Transplantation, Homologous / immunology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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