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Circulating endothelial progenitor cells as markers for severity of ischemic chronic heart failure.
MedLine Citation:
PMID:  24594088     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Despite a high potential of endothelial progenitor cells (EPC) for diagnostic purposes, the EPC role in developing ischemic chronic heart failure (CHF) has not been determined obviously. The objective of the study is to assess the counts of CD45(+)CD34(+), CD45(-)CD34(+), CD14(+)CD309(+), and CD14(+)CD309(+)Tie2(+) phenotyped circulating EPC of various subpopulations in patients with ischemic chronic heart failure (CHF).
METHODS AND RESULTS: The study involved 153 patients (86 males), aged 48 to 62 years, with angiografically proven coronary artery disease (CAD) and 25 healthy volunteers. CHF was diagnosed in 109 patients (71.2%). Mononuclear cells populations were phenotyped by flow cytofluorimetry. Cardiovascular risk factors, such as type 2 diabetes mellitus, hyperlipidemia, arterial hypertension, and adherence to smoking, may have a negative effect on circulating EPC counts in CAD patients regardless the presence of CHF. The depletion of the CD14(+)CD309(+)- and CD14(+)CD309(+)Tie-2(+)-phenotyped circulating EPC counts is associated with the severity of left ventricular dysfunction, while the CD45(+)CD34(+)- and CD45(-)CD34(+)- mononuclears counts are more representative for the severity of atherosclerotic coronary arteries lesion.
CONCLUSION: The authors found that NYHA functional class of CHF, LVEF less than 42%, the NT-pro-BNP level over 554 pg/mL, and the Е/Еm ratio over 15 U had the highest predictive value for the depletion of the EPC count in CAD patients.
Authors:
Alexander E Berezin; Alexander A Kremzer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-1
Journal Detail:
Title:  Journal of cardiac failure     Volume:  -     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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