Document Detail

Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality.
MedLine Citation:
PMID:  19173675     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to assess whether EPC (endothelial progenitor cell) number/function might be an explanatory factor for the observed relationship between Type D personality (a joint tendency towards negative affectivity and social inhibition) and poor cardiovascular prognosis. We also assessed whether the effect of a single exercise bout on EPC number/function was affected by Type D personality. A total of 35 sedentary men with CHF (chronic heart failure; left ventricular ejection fraction <or=45%) underwent CPET (cardiopulmonary exercise testing) and personality assessment with the 14-item Type D scale. CD34+/KDR (kinase insert domain-containing receptor)+ cells were quantified by flow cytometry before and immediately after CPET. Migration of early EPC towards VEGF (vascular endothelial growth factor) and SDF-1alpha (stromal-cell-derived factor-1alpha) was investigated. Type D (n=10) and non-Type D (n=25) patients were comparable with regards to demographics, disease severity and Framingham risk factor score. Circulating EPC numbers were reduced by 54% in Type D compared with non-Type D patients (0.084+/-0.055 and 0.183+/-0.029% of lymphocytes respectively; P=0.006). Exercise led to a 60% increase in EPC in Type D patients, whereas the EPC number remained unchanged in the non-Type D group (P=0.049). Baseline migratory capacity was related to disease severity, but was not different between Type D and non-Type D patients. Exercise induced a highly significant enhancement of migratory capacity in both groups. In conclusion, reduced EPC numbers might explain the impaired cardiovascular outcome in Type D patients. The larger increase in circulating EPCs observed in these patients suggests that acute exercise elicits a more pronounced stimulus for endothelial repair.
Emeline M Van Craenenbroeck; Johan Denollet; Bernard P Paelinck; Paul Beckers; Nadine Possemiers; Vicky Y Hoymans; Christiaan J Vrints; Viviane M Conraads
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-16
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  117     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-10-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Department of Cardiology, Antwerp University Hospital, Edegem, Belgium.
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MeSH Terms
Antigens, CD34 / blood
Cell Count
Endothelial Cells / pathology,  physiology
Endothelium, Vascular / pathology*,  physiopathology
Exercise / physiology
Exercise Test / methods
Heart Failure / blood,  physiopathology,  psychology*
Middle Aged
Personality Assessment
Stem Cells / pathology*,  physiology
Vascular Endothelial Growth Factor Receptor-2 / blood
Reg. No./Substance:
0/Antigens, CD34; EC Endothelial Growth Factor Receptor-2

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