| Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality. | |
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MedLine Citation:
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PMID: 19173675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to assess whether EPC (endothelial progenitor cell) number/function might be an explanatory factor for the observed relationship between Type D personality (a joint tendency towards negative affectivity and social inhibition) and poor cardiovascular prognosis. We also assessed whether the effect of a single exercise bout on EPC number/function was affected by Type D personality. A total of 35 sedentary men with CHF (chronic heart failure; left ventricular ejection fraction <or=45%) underwent CPET (cardiopulmonary exercise testing) and personality assessment with the 14-item Type D scale. CD34+/KDR (kinase insert domain-containing receptor)+ cells were quantified by flow cytometry before and immediately after CPET. Migration of early EPC towards VEGF (vascular endothelial growth factor) and SDF-1alpha (stromal-cell-derived factor-1alpha) was investigated. Type D (n=10) and non-Type D (n=25) patients were comparable with regards to demographics, disease severity and Framingham risk factor score. Circulating EPC numbers were reduced by 54% in Type D compared with non-Type D patients (0.084+/-0.055 and 0.183+/-0.029% of lymphocytes respectively; P=0.006). Exercise led to a 60% increase in EPC in Type D patients, whereas the EPC number remained unchanged in the non-Type D group (P=0.049). Baseline migratory capacity was related to disease severity, but was not different between Type D and non-Type D patients. Exercise induced a highly significant enhancement of migratory capacity in both groups. In conclusion, reduced EPC numbers might explain the impaired cardiovascular outcome in Type D patients. The larger increase in circulating EPCs observed in these patients suggests that acute exercise elicits a more pronounced stimulus for endothelial repair. |
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Authors:
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Emeline M Van Craenenbroeck; Johan Denollet; Bernard P Paelinck; Paul Beckers; Nadine Possemiers; Vicky Y Hoymans; Christiaan J Vrints; Viviane M Conraads |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-16 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 117 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-15 Completed Date: 2009-10-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 165-72 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Antwerp University Hospital, Edegem, Belgium. emeline.vancraenenbroeck@ua.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD34 / blood Cell Count Endothelial Cells / pathology, physiology Endothelium, Vascular / pathology*, physiopathology Exercise / physiology Exercise Test / methods Heart Failure / blood, physiopathology, psychology* Humans Male Middle Aged Negativism* Personality Assessment Stem Cells / pathology*, physiology Vascular Endothelial Growth Factor Receptor-2 / blood |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
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