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Circulating endothelial and progenitor cells: Evidence from acute and long-term exercise effects.
MedLine Citation:
PMID:  23272272     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are capable of maintaining, generating, and replacing terminally differentiated cells within their own specific tissue as a consequence of physiological cell turnover or tissue damage due to injury. Endothelium maintenance and restoration of normal endothelial cell function is guaranteed by a complex physiological procedure in which EPCs play a significant role. Decreased number of peripheral blood EPCs has been associated with endothelial dysfunction and high cardiovascular risk. In this review, we initially report current knowledge with regard to the role of EPCs in healthy subjects and the clinical value of EPCs in different disease populations such as arterial hypertension, obstructive sleep-apnea syndrome, obesity, diabetes mellitus, peripheral arterial disease, coronary artery disease, pulmonary hypertension, and heart failure. Recent studies have introduced the novel concept that physical activity, either performed as a single exercise session or performed as part of an exercise training program, results in a significant increase of circulating EPCs. In the second part of this review we provide preliminary evidence from recent studies investigating the effects of acute and long-term exercise in healthy subjects and athletes as well as in disease populations.
Authors:
Matina Koutroumpi; Stavros Dimopoulos; Katherini Psarra; Theodoros Kyprianou; Serafim Nanas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of cardiology     Volume:  4     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-28     Completed Date:  2012-12-31     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  312-26     Citation Subset:  -    
Affiliation:
Matina Koutroumpi, Stavros Dimopoulos, Serafim Nanas, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, 1st Critical Care Medicine Department, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.
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