Document Detail


Circulating endothelial cells and tumor blood volume as predictors in lung cancer.
MedLine Citation:
PMID:  23298271     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The current criteria for evaluating antiangiogenic efficacy is insufficient as tumor shrinkage occurs after blood perfusion decreases. Tumor blood volume (BV) in CT perfusion imaging, and circulating endothelial cells (CECs) may predict the status of angiogenesis. The present study aimed to validate their representation as feasible predictors in non-small-cell lung carcinoma (NSCLC). A total of 74 patients were categorized randomly into two arms undergoing regimens of vinorelbine and cisplatin (Navelbine and platinum, NP) with rh-endostatin or single NP. The response rate, perfusion imaging indexes, and activated CECs (aCECs) during treatment were recorded. Progression free survival (PFS) was determined through follow-up. The correlations among above indicators, response, and PFS were analyzed: aCECs increased significantly in cases of progressive disease (PD) after single NP chemotherapy (P = 0.024). The tumor BV decreased significantly in cases with clinical benefit in combined arm (P = 0.026), whereby inverse correlations existed between ∆aCECs (the post-therapeutic value minus the pre-therapeutic value) and PFS (P = 0.005), and between ∆BV and PFS (P = 0.044); and positive correlation existed between ∆aCECs and ∆BV. Therefore, both aCECs and tumor BV can serve as predictors, and detection of both indicators can help evaluate the chemo-antiangiogenic efficacy in NSCLC more accurately.
Authors:
Jing Wang; Jianyu Xiao; Xiyin Wei; Liuchun Wang; Li Lin; Zhujun Liu; Xinyue Wang; Baocun Sun; Kai Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Cancer Association.
Affiliation:
Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
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