Document Detail


Circulating endogenous cannabinoid anandamide and portal, systemic and renal hemodynamics in cirrhosis.
MedLine Citation:
PMID:  15482346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Endocannabinoids may participate in the homeostasis of arterial pressure. Recently, anandamide, the most extensively studied endocannabinoid, has been proposed as a key mediator in the peripheral arterial vasodilation of cirrhosis. OBJECTIVES: To determine if circulating levels of anandamide are related to the extent of the peripheral arterial vasodilation, the severity of portal hypertension and the degree of liver and renal dysfunction of patients with cirrhosis. METHODS: Plasma levels of anandamide and several systemic, portal and renal hemodynamic parameters were determined in 18 patients with cirrhosis and eight healthy subjects (control group). RESULTS: Plasma levels of anandamide were elevated in patients compared to the control group (P<0.05), nevertheless, no differences between patients with ascites and well-compensated patients were found. There was no correlation between anandamide concentration and arterial pressure, cardiac output and systemic vascular resistance, Child-Pugh's score, portal pressure, renal vascular resistance, plasma renin activity or plasma aldosterone concentration. CONCLUSIONS: Circulating levels of anandamide are increased in cirrhotic patients. However, this elevation was unrelated to the extent of arterial vasodilation, the severity of portal hypertension or the degree of hepatic and renal dysfunction. Although a local hormonal action cannot be excluded, our results do not support a relevant contribution of this system in the hemodynamic disturbance of cirrhosis.
Authors:
Conrado M Fernández-Rodriguez; Julian Romero; Timothy J Petros; Heather Bradshaw; José M Gasalla; Maria Luisa Gutiérrez; José L Lledó; Cecilio Santander; Teresa Pérez Fernández; Esperanza Tomás; Guillermo Cacho; J Michael Walker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  24     ISSN:  1478-3223     ISO Abbreviation:  Liver Int.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-14     Completed Date:  2005-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  477-83     Citation Subset:  IM    
Affiliation:
Unit of Gastroenterology and Laboratory of Research, Fundación Hospital Alcorcón, 28922 Madrid, Spain. cfernandez@fhalcorcon.es
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / blood*
Endocannabinoids / blood*
Female
Glomerular Filtration Rate*
Humans
Hypertension, Portal / blood,  etiology,  physiopathology*
Liver Cirrhosis / blood,  complications,  physiopathology*
Male
Middle Aged
Polyunsaturated Alkamides
Stroke Volume / physiology
Vascular Resistance / physiology
Grant Support
ID/Acronym/Agency:
DA13012/DA/NIDA NIH HHS; K02DA00375/DA/NIDA NIH HHS; NS33247/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Endocannabinoids; 0/Polyunsaturated Alkamides; 94421-68-8/anandamide

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