Document Detail

Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions.
MedLine Citation:
PMID:  10967006     Owner:  NLM     Status:  MEDLINE    
Concentrations of the T-helper (Th) 1 cytokines interleukin (IL)-2, tumour necrosis factor (TNF) -alpha, TNF-beta and interferon-gamma, Th2 cytokines IL-4, IL-5, IL-6, IL-10 as well as those of soluble CD30 in sera have been examined during the three trimesters of gestation, at delivery in normal pregnancy, and at the time of spontaneous abortion in women with a history of unexplained recurrent spontaneous abortion (RSA). Significantly higher concentrations of the Th2 cytokines IL-6 and IL-10 were found at normal delivery than in women with RSA, and conversely significantly increased concentrations of the Th1-type cytokine TNF-alpha were found in RSA as compared with successful pregnancy. In abortion-prone women who had a successful pregnancy, significantly higher concentrations of IL-6 and significantly lower concentrations of TNF-alpha were found as compared with abortion-prone women who had another abortion, supporting the notion that Th2- and Th1-bias are associated with successful and unsuccessful pregnancy respectively. Serum CD30 concentrations did not correlate with the outcome of pregnancy. These findings support observations drawn from experiments on the cytokine secretion profiles of peripheral blood mononuclear cells and decidual lymphocytes which suggest that normal pregnancy is Th2-biased and that unexplained RSA is associated with Th1-type reactivity.
M Makhseed; R Raghupathy; F Azizieh; R Farhat; N Hassan; A Bandar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2011-7     Citation Subset:  IM    
Departments of 1Obstetrics and Gynecology and Microbiology, Faculty of Medicine, Kuwait University, and Maternity Hospital, Kuwait.
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MeSH Terms
Abortion, Habitual / immunology*
Antigens, CD30 / blood*
Cytokines / blood*
Gestational Age
Interferon-gamma / blood
Interleukin-10 / blood
Interleukin-2 / blood
Interleukin-4 / blood
Interleukin-5 / blood
Interleukin-6 / blood
Lymphotoxin-alpha / blood
T-Lymphocytes, Helper-Inducer / immunology
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Antigens, CD30; 0/Cytokines; 0/Interleukin-2; 0/Interleukin-5; 0/Interleukin-6; 0/Lymphotoxin-alpha; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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