Document Detail


Circulating carrier erythrocytes: slow-release vehicle for an antileukemic drug, cytosine arabinoside.
MedLine Citation:
PMID:  7165167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human anti-cancer drug Cytosine arabinoside (ana-C) was encapsulated in canine erythrocytes. When these autologous carrier cells were injected into dogs, the drug was slowly released into plasma. Erythrocyte encapsulation increased the plasma half-life of ara-C in dogs about 50-fold over that of the injected free drug. The whole blood half-life of encapsulated drug was 4.6 days and the elimination constant was 0.150 day-1. Erythrocyte encapsulation holds promise as a drug-delivering technique for treatment of some human and animal diseases, particularly with drugs that are highly toxic or have normally short biological half-life. It also could be used to sustain given concentrations of drugs.
Authors:
J R DeLoach; C Barton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  43     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2210-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytarabine / administration & dosage*,  blood
Delayed-Action Preparations
Dogs / blood*
Erythrocytes*
Half-Life
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 147-94-4/Cytarabine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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