Document Detail

Circulating cardiovascular biomarkers in recurrent atrial fibrillation: data from the GISSI-atrial fibrillation trial.
MedLine Citation:
PMID:  20964739     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: we evaluated the prognostic role of circulating cardiovascular biomarkers in patients with a history of recent atrial fibrillation (AF).
BACKGROUND: predicting long-term maintenance of sinus rhythm in patients with AF is difficult.
METHODS: plasma concentrations of three specific cardiac markers [high-sensitivity troponin T (hsTnT), N-terminal probrain natriuretic peptide (NT-proBNP) and mid-regional proatrial natriuretic peptide (MR-proANP)] and three stable fragments of vasoactive peptides [mid-regional proadrenomedullin (MR-proADM), copeptin (CT-proAVP) and CT-proendothelin-1 (CT-proET-1)] were measured at baseline and after 6 and 12 months in 382 patients enrolled in the GISSI-AF study, a prospective randomized trial to determine the effect of valsartan to reduce the recurrence of AF. The association between these markers, clinical characteristics and recurrence of AF was tested by univariate and multivariate Cox models.
RESULTS: mean patient age was 68 ± 9 years (37.2% females). A total of 84.8% of patients had a history of hypertension. In total, 59.7% qualified for history of AF because of successful cardioversion, 11.8% because of two or more episodes of AF in the 6 months preceding randomization and 28.5% because of both. Patients in AF at 6 or 12 months (203 (53.1%) with first recurrence) had significantly higher concentrations of most biomarkers. Despite low baseline levels, higher concentrations of hsTnT {adjusted hazard ratio (HR) [95% confidence intervals (CIs) for 1 SD increment] (1.15 [1.04-1.28], P = 0.007), MR-proANP (1.15 [1.01-1.30], P = 0.04), NT-proBNP (1.24 [1.11-1.39], P = 0.0001) and CT-proET-1 (1.16 [1.01-1.33], P = 0.03) independently predicted higher risk of a first recurrence of AF. Changes over time of MR-proANP tended to predict subsequent recurrence (adjusted HR [95%CI]) (1.53 [0.98-2.37], P = 0.06).
CONCLUSION: circulating markers of cardiomyocyte injury/strain and endothelin are related to recurrence of AF in patients in sinus rhythm with a history of recent AF.
R Latini; S Masson; S Pirelli; S Barlera; G Pulitano; E Carbonieri; M Gulizia; T Vago; C Favero; D Zdunek; J Struck; L Staszewsky; A P Maggioni; M G Franzosi; M Disertori;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-22
Journal Detail:
Title:  Journal of internal medicine     Volume:  269     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-02-16     Revised Date:  2013-02-07    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-71     Citation Subset:  IM    
Istituto di Ricerche Farmacologiche "Mario Negri", Milan Istituti Ospitalieri, Cremona POL Madonna della Consolazione, Reggio Calabria, Italy.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / therapeutic use
Atrial Fibrillation / blood,  diagnosis*,  prevention & control
Biological Markers / blood*
Epidemiologic Methods
Hospitalization / statistics & numerical data
Middle Aged
Natriuretic Peptides / blood
Recurrence / prevention & control
Tetrazoles / therapeutic use
Troponin T / blood
Valine / analogs & derivatives,  therapeutic use
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Biological Markers; 0/Natriuretic Peptides; 0/Tetrazoles; 0/Troponin T; 137862-53-4/valsartan; 7004-03-7/Valine

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