Document Detail

Circulating cardiac troponin I levels in Kawasaki disease.
MedLine Citation:
PMID:  11178661     Owner:  NLM     Status:  MEDLINE    
In addition to the vascular findings of Kawasaki disease (KD), clinical, electrocardiographic, and/or echocardiographic signs of myocarditis are recognizable in the acute phase of KD in many patients. The mechanism of myocarditis and an association with the development of subsequent coronary artery abnormalities in KD is unknown. Previous studies of serum cardiac troponin I (cTnI) measurements in pediatric populations have suggested a possible utility of measurements in diagnosis and follow-up of KD. We designed a retrospective study to evaluate cTnI measurements during acute KD and to assess the predictive value of cTnI measurements in acute KD for the subsequent development of coronary artery abnormalities. Twenty-nine children were studied. Group 1 consisted of 15 KD patients who developed coronary artery abnormalities as detected by transthoracic echocardiographic evaluation. Group 2 consisted of 14 KD patients with persistently normal coronary artery findings on echocardiograms. A control group consisted of 11 children, none of whom were known to have had clinical findings of KD or myocarditis. The mean cTnI values for all three groups were lower than the values suggestive of cardiac damage: group 1 = 0.11 +/- 0.16 ng/ml, group 2 = 0.15 +/- 0.34 ng/ml, and control = 0.04 +/- 0.08 ng/ml. The current study demonstrates that there is no significant elevation of cTnI in KD patients. Additionally, there is no correlation between cTnI measurements and the finding of myocarditis, as reflected by decreased cardiac function, or the subsequent development of coronary artery abnormalities.
P A Checchia; J Borensztajn; S T Shulman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  22     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-05-03     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-6     Citation Subset:  IM    
Department of Pediatrics, Loma Linda University Children's Hospital, CA 92350, USA.
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MeSH Terms
Acute Disease
Child, Preschool
Mucocutaneous Lymph Node Syndrome / blood*,  ultrasonography
Retrospective Studies
Troponin I / blood*
Reg. No./Substance:
0/Troponin I

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