Document Detail


Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants.
MedLine Citation:
PMID:  19755933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Matrix metalloproteinases (MMPs) and chemokines seem to be induced by hyperoxia in preclinical studies. We hypothesized that O2 exposure immediately after birth is associated with altered blood spot MMP 9 and beta chemokine concentrations. The following analytes were measured on blood spots on d 1 and 3 of life, using luminex technology in 1059 infants (birth weights <1000 g) in the NICHD Neonatal Research Network: MMP 9, monocyte chemoattractant protein 1 (MCP 1), macrophage inflammatory proteins (1alpha and beta), and regulated upon activation, normal t cell expressed and secreted (RANTES). Infants administered O2 continually from 6 to 24 h of life (n = 729), when compared with those with <6 h exposure (n = 330), had significantly lower mean birth weight and higher rate of respiratory distress syndrome (p < 0.002). On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure. After adjusting for covariates, prolonged early O2 exposure retained a statistically significant association with higher MCP 1 on d 3 (p = 0.003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted.
Authors:
Girija Natarajan; Seetha Shankaran; Scott A McDonald; Abhik DAS; Barbara J Stoll; Rosemary D Higgins; Poul Thorsen; Kristin Skogstrand; David M Hougaard; Waldemar A Carlo;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-03-25     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chemokines, CC / metabolism*
Enzyme-Linked Immunosorbent Assay
Humans
Infant, Extremely Low Birth Weight*
Infant, Newborn
Matrix Metalloproteinase 9 / metabolism*
Grant Support
ID/Acronym/Agency:
5 M01 RR00044/RR/NCRR NIH HHS; M01 RR 00039/RR/NCRR NIH HHS; M01 RR 00070/RR/NCRR NIH HHS; M01 RR 00125/RR/NCRR NIH HHS; M01 RR 0039-43/RR/NCRR NIH HHS; M01 RR 00750/RR/NCRR NIH HHS; M01 RR 08084/RR/NCRR NIH HHS; R03 HD054420/HD/NICHD NIH HHS; U10 HD021373-15/HD/NICHD NIH HHS; U10 HD021385-14/HD/NICHD NIH HHS; U10 HD021397-14/HD/NICHD NIH HHS; U10 HD027851-09/HD/NICHD NIH HHS; U10 HD027853/HD/NICHD NIH HHS; U10 HD027853-16/HD/NICHD NIH HHS; U10 HD027856-09/HD/NICHD NIH HHS; U10 HD027871-09/HD/NICHD NIH HHS; U10 HD027880-09/HD/NICHD NIH HHS; U10 HD027904-09/HD/NICHD NIH HHS; U10 HD034216-04/HD/NICHD NIH HHS; U10 HD036790-11/HD/NICHD NIH HHS; U10 HD040461-01/HD/NICHD NIH HHS; U10 HD040492/HD/NICHD NIH HHS; U10 HD040492-01/HD/NICHD NIH HHS; U10 HD040521/HD/NICHD NIH HHS; U10 HD040521-01/HD/NICHD NIH HHS; U10 HD040689-06/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; UL1 RR025008/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chemokines, CC; EC 3.4.24.35/Matrix Metalloproteinase 9
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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