| Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants. | |
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MedLine Citation:
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PMID: 19755933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Matrix metalloproteinases (MMPs) and chemokines seem to be induced by hyperoxia in preclinical studies. We hypothesized that O2 exposure immediately after birth is associated with altered blood spot MMP 9 and beta chemokine concentrations. The following analytes were measured on blood spots on d 1 and 3 of life, using luminex technology in 1059 infants (birth weights <1000 g) in the NICHD Neonatal Research Network: MMP 9, monocyte chemoattractant protein 1 (MCP 1), macrophage inflammatory proteins (1alpha and beta), and regulated upon activation, normal t cell expressed and secreted (RANTES). Infants administered O2 continually from 6 to 24 h of life (n = 729), when compared with those with <6 h exposure (n = 330), had significantly lower mean birth weight and higher rate of respiratory distress syndrome (p < 0.002). On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure. After adjusting for covariates, prolonged early O2 exposure retained a statistically significant association with higher MCP 1 on d 3 (p = 0.003). The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted. |
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Authors:
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Girija Natarajan; Seetha Shankaran; Scott A McDonald; Abhik DAS; Barbara J Stoll; Rosemary D Higgins; Poul Thorsen; Kristin Skogstrand; David M Hougaard; Waldemar A Carlo; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatric research Volume: 67 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-25 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. gnatara@med.wayne.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemokines, CC
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metabolism* Enzyme-Linked Immunosorbent Assay Humans Infant, Extremely Low Birth Weight* Infant, Newborn Matrix Metalloproteinase 9 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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5 M01 RR00044/RR/NCRR NIH HHS; M01 RR 00039/RR/NCRR NIH HHS; M01 RR 00070/RR/NCRR NIH HHS; M01 RR 00125/RR/NCRR NIH HHS; M01 RR 0039-43/RR/NCRR NIH HHS; M01 RR 00750/RR/NCRR NIH HHS; M01 RR 08084/RR/NCRR NIH HHS; R03 HD054420/HD/NICHD NIH HHS; U10 HD021373-15/HD/NICHD NIH HHS; U10 HD021385-14/HD/NICHD NIH HHS; U10 HD021397-14/HD/NICHD NIH HHS; U10 HD027851-09/HD/NICHD NIH HHS; U10 HD027853-16/HD/NICHD NIH HHS; U10 HD027856-09/HD/NICHD NIH HHS; U10 HD027871-09/HD/NICHD NIH HHS; U10 HD027880-09/HD/NICHD NIH HHS; U10 HD027904-09/HD/NICHD NIH HHS; U10 HD034216-04/HD/NICHD NIH HHS; U10 HD036790-11/HD/NICHD NIH HHS; U10 HD040461-01/HD/NICHD NIH HHS; U10 HD040492-01/HD/NICHD NIH HHS; U10 HD040521-01/HD/NICHD NIH HHS; U10 HD040689-06/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40492/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS; UL1 RR025008/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokines, CC; EC 3.4.24.35/Matrix Metalloproteinase 9 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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