Document Detail


Circulating beta amyloid protein is elevated in patients with acute ischemic stroke.
MedLine Citation:
PMID:  15682267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease (AD). Beta amyloid (Abeta), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Abeta and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Abeta level between each subgroup. The Abeta1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg/ml, p<0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher Abeta1-40 level than small vessel disease (p = 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of Abeta1-40 (r = 0.539, p<0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum Abeta1-40. Our data suggest that elevated circulating Abeta1-40 in ischemic stroke patients may be derived from brain as a consequence of ischemic insults.
Authors:
P H Lee; O Y Bang; E M Hwang; J S Lee; U S Joo; I Mook-Jung; K Huh
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Publication Detail:
Type:  Journal Article     Date:  2005-01-31
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  112     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2006-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1371-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Amyloid beta-Protein / blood*
Biological Markers / blood
Brain Ischemia / epidemiology,  metabolism*,  pathology
Female
Humans
Male
Middle Aged
P-Selectin / blood
Peptide Fragments / blood*
Platelet Activation
Prospective Studies
Risk Factors
Severity of Illness Index
Stroke / epidemiology,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Biological Markers; 0/P-Selectin; 0/Peptide Fragments; 0/amyloid beta-protein (1-40)

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