Document Detail


Circulating antibodies against human colonic extract enriched with a 40 kDa protein in patients with ulcerative colitis.
MedLine Citation:
PMID:  2210446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously described a 40 kDa colonic protein(s) which is specifically recognised by tissue-bound immunoglobulin G obtained from the colon of patients with ulcerative colitis. We now report the presence of circulating antibodies against this antigen using an enzyme-linked immunosorbent assay with a highly enriched preparation of the 40 kDa protein from normal colon extracts. Serum was collected from 79 patients with ulcerative colitis, 36 with Crohn's disease, 16 with specific diarrhoeal syndromes, and from 19 normal subjects. Twenty nine of 79 patients with ulcerative colitis, 21 of 36 with Crohn's disease, and all patients with diarrhoea were symptomatic during the collection of sera. The difference in optical density values between patients with symptomatic ulcerative colitis and each of the other groups, including patients with ulcerative colitis in remission, was highly significant (p less than 0.01). Seventy nine per cent of patients with symptomatic ulcerative colitis had optical density values above the means for all other groups. Fifty five per cent of sera from patients with symptomatic ulcerative colitis had optical densities beyond two SDs of the values for all other groups and only two of 71 sera from non-ulcerative colitis patients (one Crohn's disease and one normal subject) had values in this range. These results show the presence of anti-colon antibodies against the 40 kDa protein(s) in the sera of many patients with symptomatic ulcerative colitis.
Authors:
F Takahasi; H S Shah; L S Wise; K M Das
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  31     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-01     Completed Date:  1990-11-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1016-20     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Medicine of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08904.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibody Specificity
Autoantibodies / analysis*,  immunology
Autoantigens / immunology*
Colitis, Ulcerative / immunology*
Colon / immunology*
Crohn Disease / immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens
Comments/Corrections

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