Document Detail


Circulating angiogenic and inflammatory cytokine responses to acute aerobic exercise in trained and sedentary young men.
MedLine Citation:
PMID:  24643426     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Endurance exercise training can ameliorate many cardiovascular and metabolic disorders and attenuate responses to inflammatory stimuli. The purpose of this study was to determine whether the angiogenic and pro-inflammatory cytokine response to acute endurance exercise differs between endurance-trained and sedentary young men.
METHODS: Ten endurance-trained and ten sedentary healthy young men performed 30 min of treadmill running at 75 % VO2max with blood sampling before and after exercise. Plasma concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), placental growth factor (PlGF), and soluble VEGF receptor-1 (sFlt-1) were measured by multiplex ELISA.
RESULTS: Acute exercise increased IL-6 by 165 % (P < 0.05), IL-8 by 32 % (P < 0.05), PlGF by ~16 % (P < 0.05), sFlt-1 by 36 % (P < 0.001), and tended to increase bFGF by ~25 % (P = 0.06) in main effects analyses. TNF-α and VEGF did not change significantly with exercise in either group. Contrary to our hypothesis, there were no significant differences in TNF-α, IL-6, VEGF, bFGF, PlGF, or sFlt-1 between groups before or after acute exercise; however, there was a tendency for IL-8 concentrations to be higher in endurance-trained subjects compared to sedentary subjects (P = 0.06).
CONCLUSIONS: These results indicate that 30 min of treadmill running at 75 % VO2max produces a systemic angiogenic and inflammatory reaction, but endurance exercise training does not appear to significantly alter these responses in healthy young men.
Authors:
Rian Q Landers-Ramos; Nathan T Jenkins; Espen E Spangenburg; James M Hagberg; Steven J Prior
Related Documents :
23178146 - Resistance exercise modulates lipid plasma profile and cytokine content in the adipose ...
9361696 - Effect of muscular exercise on the concentration of uridine and purine bases in plasma-...
2851526 - Acute exercise stimulates the renin-angiotensin-aldosterone axis: adaptive changes in r...
6143566 - Bopindolol: a new long acting beta-receptor antagonist; its effects on haemodynamics, a...
17089876 - Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and p...
8457806 - Abdominal muscle training in sport.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-19
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of Rotylenchulus reniformis Resistant Glycine Lines.
Next Document:  Neuromuscular function following muscular unloading and blood flow restricted exercise.