| Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. | |
| | |
MedLine Citation:
|
PMID: 16458660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Recently, reports have indicated that the imbalance of circulating angiogenic factors is important in the onset of preeclampsia. In this study we investigated angiogenic factor levels in women with preeclampsia, preeclampsia superimposed on chronic glomerulonephritis, gestational proteinuria, and normal pregnancies. STUDY DESIGN: We measured several circulating angiogenic factors, placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase-1, and soluble fetal liver kinase-1. RESULTS: Compared with women with normal pregnancies, placental growth factor concentrations were lower, and soluble fms-like tyrosine kinase 1 concentrations were higher in women with preeclampsia and gestational proteinuria; soluble fms-like tyrosine kinase 1 concentrations were also higher in women with preeclampsia superimposed on chronic glomerulonephritis. CONCLUSION: There were obvious differences in the levels of circulating angiogenic factors placental growth factor and soluble fms-like tyrosine kinase 1 among preeclampsia, gestational proteinuria, and controls. The imbalance of angiogenic factors is important in the onset of preeclampsia superimposed on chronic glomerulonephritis. |
| | |
Authors:
|
Hisashi Masuyama; Naoko Suwaki; Hideki Nakatsukasa; Akio Masumoto; Yoko Tateishi; Yuji Hiramatrsu |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 194 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2006 Feb |
Date Detail:
|
Created Date: 2006-02-06 Completed Date: 2006-04-20 Revised Date: 2009-11-25 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 551-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan. masuyama@cc.okayama-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chronic Disease Female Glomerulonephritis / blood* Humans Neovascularization, Physiologic / physiology Pre-Eclampsia / blood* Pregnancy Pregnancy Complications / blood* Pregnancy Proteins / blood* Proteinuria / physiopathology* Vascular Endothelial Growth Factor A / blood* Vascular Endothelial Growth Factor Receptor-1 / blood* Vascular Endothelial Growth Factor Receptor-2 / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term ...
Next Document: Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies compl...