Document Detail


Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis.
MedLine Citation:
PMID:  16458660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recently, reports have indicated that the imbalance of circulating angiogenic factors is important in the onset of preeclampsia. In this study we investigated angiogenic factor levels in women with preeclampsia, preeclampsia superimposed on chronic glomerulonephritis, gestational proteinuria, and normal pregnancies. STUDY DESIGN: We measured several circulating angiogenic factors, placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase-1, and soluble fetal liver kinase-1. RESULTS: Compared with women with normal pregnancies, placental growth factor concentrations were lower, and soluble fms-like tyrosine kinase 1 concentrations were higher in women with preeclampsia and gestational proteinuria; soluble fms-like tyrosine kinase 1 concentrations were also higher in women with preeclampsia superimposed on chronic glomerulonephritis. CONCLUSION: There were obvious differences in the levels of circulating angiogenic factors placental growth factor and soluble fms-like tyrosine kinase 1 among preeclampsia, gestational proteinuria, and controls. The imbalance of angiogenic factors is important in the onset of preeclampsia superimposed on chronic glomerulonephritis.
Authors:
Hisashi Masuyama; Naoko Suwaki; Hideki Nakatsukasa; Akio Masumoto; Yoko Tateishi; Yuji Hiramatrsu
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  194     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-20     Revised Date:  2009-11-25    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama, Japan. masuyama@cc.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Chronic Disease
Female
Glomerulonephritis / blood*
Humans
Neovascularization, Physiologic / physiology
Pre-Eclampsia / blood*
Pregnancy
Pregnancy Complications / blood*
Pregnancy Proteins / blood*
Proteinuria / physiopathology*
Vascular Endothelial Growth Factor A / blood*
Vascular Endothelial Growth Factor Receptor-1 / blood*
Vascular Endothelial Growth Factor Receptor-2 / blood*
Chemical
Reg. No./Substance:
0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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