Document Detail


Circulating angiogenic and antiangiogenic factors in women with eclampsia.
MedLine Citation:
PMID:  21062661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to determine whether eclampsia has a different circulating profile of angiogenic (placental growth factor [PlGF]) and antiangiogenic factors (soluble vascular endothelial growth factor receptor-1 [sVEGFR-1] and soluble endoglin [sEng]) from severe preeclampsia.
STUDY DESIGN: This cross-sectional study included pregnant women in the following groups: (1) normal pregnancy (n = 40); (2) severe preeclampsia (n = 40); and (3) eclampsia (n = 20). Maternal serum PlGF, sVEGFR-1, and sEng concentrations were determined using an enzyme-linked immunosorbent assay.
RESULTS: The study results included the following: (1) the median concentration of sVEGFR-1 and sEng was higher and of PlGF was lower in severe preeclampsia or eclampsia than in normal pregnancy (P < .001 for all); and (2) the median concentrations of these 3 analytes did not differ significantly between patients with severe preeclampsia and those with eclampsia.
CONCLUSION: Eclampsia is associated with higher maternal circulating concentrations of sVEGFR-1 and sEng and lower concentrations of PlGF than normal pregnancy but with similar concentrations to severe preeclampsia. These findings suggest that eclampsia shares a common pathogenic pathway as severe preeclampsia.
Authors:
Edi Vaisbuch; Janice E Whitty; Sonia S Hassan; Roberto Romero; Juan Pedro Kusanovic; David B Cotton; Yoram Sorokin; S Ananth Karumanchi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-09
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-03-14     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152.e1-9     Citation Subset:  AIM; IM    
Copyright Information:
Published by Mosby, Inc.
Affiliation:
Perinatology Research Branch, Intramural Division, the Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Hutzel Women's Hospital, Bethesda, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Antigens, CD / blood*
Cross-Sectional Studies
Eclampsia / blood*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Pre-Eclampsia / blood*
Pregnancy
Pregnancy Proteins / blood*
Receptors, Cell Surface / blood*
Severity of Illness Index
Vascular Endothelial Growth Factor Receptor-1 / blood*
Grant Support
ID/Acronym/Agency:
ZIA HD002400-19/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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