| Circulating angiogenic and antiangiogenic factors in women with eclampsia. | |
| | |
MedLine Citation:
|
PMID: 21062661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The objective of the study was to determine whether eclampsia has a different circulating profile of angiogenic (placental growth factor [PlGF]) and antiangiogenic factors (soluble vascular endothelial growth factor receptor-1 [sVEGFR-1] and soluble endoglin [sEng]) from severe preeclampsia. STUDY DESIGN: This cross-sectional study included pregnant women in the following groups: (1) normal pregnancy (n = 40); (2) severe preeclampsia (n = 40); and (3) eclampsia (n = 20). Maternal serum PlGF, sVEGFR-1, and sEng concentrations were determined using an enzyme-linked immunosorbent assay. RESULTS: The study results included the following: (1) the median concentration of sVEGFR-1 and sEng was higher and of PlGF was lower in severe preeclampsia or eclampsia than in normal pregnancy (P < .001 for all); and (2) the median concentrations of these 3 analytes did not differ significantly between patients with severe preeclampsia and those with eclampsia. CONCLUSION: Eclampsia is associated with higher maternal circulating concentrations of sVEGFR-1 and sEng and lower concentrations of PlGF than normal pregnancy but with similar concentrations to severe preeclampsia. These findings suggest that eclampsia shares a common pathogenic pathway as severe preeclampsia. |
| | |
Authors:
|
Edi Vaisbuch; Janice E Whitty; Sonia S Hassan; Roberto Romero; Juan Pedro Kusanovic; David B Cotton; Yoram Sorokin; S Ananth Karumanchi |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-09 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 204 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-02 Completed Date: 2011-03-14 Revised Date: 2012-02-01 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 152.e1-9 Citation Subset: AIM; IM |
Copyright Information:
|
Published by Mosby, Inc. |
Affiliation:
|
Perinatology Research Branch, Intramural Division, the Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Hutzel Women's Hospital, Bethesda, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analysis of Variance Antigens, CD / blood* Cross-Sectional Studies Eclampsia / blood* Enzyme-Linked Immunosorbent Assay Female Humans Pre-Eclampsia / blood* Pregnancy Pregnancy Proteins / blood* Receptors, Cell Surface / blood* Severity of Illness Index Vascular Endothelial Growth Factor Receptor-1 / blood* |
| Grant Support | |
ID/Acronym/Agency:
|
ZIA HD002400-19/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/ENG protein, human; 0/Pregnancy Proteins; 0/Receptors, Cell Surface; 144589-93-5/placenta growth factor; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced change detection performance reveals improved strategy use in avid action video game player...
Next Document: Cecocolic intussusception.