Document Detail

Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study.
MedLine Citation:
PMID:  18337619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro. We investigated the role of adiponectin and leptin levels in the etiopathogenesis of myelodysplastic syndromes (MDS), a preleukemic condition with increasing incidence which has recently been associated with obesity. METHODS: In a case-control study, 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age were studied between 2004 and 2007, and blood samples were collected. RESULTS: Higher serum adiponectin levels were associated with lower risk of MDS by bivariate analysis and after adjusting for age, gender, body mass index and serum levels of leptin (p < 0.001). Subjects in the third quartile for leptin levels had a lower risk of MDS than controls, and low leptin concentrations were observed in low-risk MDS patients with normal or good prognostic karyotype after adjusting for age, gender and body mass index. CONCLUSIONS: Circulating adiponectin and leptin may play an important role in MDS etiopathogenesis. Future studies are needed to confirm these associations and to explore underlying mechanisms.
Maria Dalamaga; Athina Nikolaidou; Konstantinos Karmaniolas; Alex Hsi; John Chamberland; Amalia Dionyssiou-Asteriou; Christos S Mantzoros
Related Documents :
8683539 - Obesity in bahraini adults.
2071319 - Effect of obesity on left ventricular function studied by radionuclide angiocardiography.
8022039 - Increasing prevalence of overweight among us adults. the national health and nutrition ...
9037799 - A study of pattern of body mass index (bmi) and prevalence of obesity in a saudi popula...
17156939 - Index of central obesity - a novel parameter.
18234399 - Abdominal obesity is associated with autonomic nervous derangement in healthy asian obe...
24126969 - Physical activity and improved diastolic function in spinal cord-injured subjects.
24328209 - Detection of the oxygen consumption rate of migrating zebrafish by electrochemical equa...
11228079 - Alcohol and suicide in 14 european countries.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-13
Journal Detail:
Title:  Oncology     Volume:  73     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2007  
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel
Department of Clinical Biochemistry, Medical School, University of Athens, Attikon General University Hospital, Chaidari, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adiponectin / blood*
Biological Markers / blood
Case-Control Studies
Leptin / blood*
Leukemia / blood,  etiology
Middle Aged
Myelodysplastic Syndromes / blood*,  etiology*
Obesity / blood,  complications*
Precancerous Conditions / blood*,  etiology*
Predictive Value of Tests
Tumor Markers, Biological / blood
Grant Support
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Leptin; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  HPV and cervical cancer testing and prevention: knowledge, beliefs, and attitudes among Hispanic wom...
Next Document:  Potential prognostic benefits of radiotherapy as an initial treatment for patients with unresectable...