Document Detail


Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study.
MedLine Citation:
PMID:  18337619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Adiponectin plays a protective role in several malignancies, including myeloblastic leukemia, whereas leptin may increase the proliferation of progenitor cells and may stimulate leukemic cell growth in vitro. We investigated the role of adiponectin and leptin levels in the etiopathogenesis of myelodysplastic syndromes (MDS), a preleukemic condition with increasing incidence which has recently been associated with obesity. METHODS: In a case-control study, 101 cases with incident, histologically confirmed primary MDS and 101 controls matched on gender and age were studied between 2004 and 2007, and blood samples were collected. RESULTS: Higher serum adiponectin levels were associated with lower risk of MDS by bivariate analysis and after adjusting for age, gender, body mass index and serum levels of leptin (p < 0.001). Subjects in the third quartile for leptin levels had a lower risk of MDS than controls, and low leptin concentrations were observed in low-risk MDS patients with normal or good prognostic karyotype after adjusting for age, gender and body mass index. CONCLUSIONS: Circulating adiponectin and leptin may play an important role in MDS etiopathogenesis. Future studies are needed to confirm these associations and to explore underlying mechanisms.
Authors:
Maria Dalamaga; Athina Nikolaidou; Konstantinos Karmaniolas; Alex Hsi; John Chamberland; Amalia Dionyssiou-Asteriou; Christos S Mantzoros
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-13
Journal Detail:
Title:  Oncology     Volume:  73     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2007  
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel
Affiliation:
Department of Clinical Biochemistry, Medical School, University of Athens, Attikon General University Hospital, Chaidari, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Aged
Biological Markers / blood
Case-Control Studies
Female
Humans
Leptin / blood*
Leukemia / blood,  etiology
Male
Middle Aged
Myelodysplastic Syndromes / blood*,  etiology*
Obesity / blood,  complications*
Precancerous Conditions / blood*,  etiology*
Predictive Value of Tests
Prognosis
Tumor Markers, Biological / blood
Grant Support
ID/Acronym/Agency:
R01 DK58785/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Leptin; 0/Tumor Markers, Biological

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