| Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure. | |
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MedLine Citation:
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PMID: 23013043 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each patient. The severity of HF was determined by the NYHA (New York Heart Association) classification system. After adjustments for age, gender and BMI, serum A-FABP concentrations in patients with HF were significantly higher than in non-HF patients [11.17 (6.63-19.93) ng/ml compared with 5.67 (3.20-8.87) ng/ml; P<0.001] and significantly progressed with the NYHA class (P<0.001). In addition, NT-proBNP (N-terminal pro-brain natriuretic peptide) was independently and positively correlated with A-FABP (standardized β=0.340, P<0.001) after adjusting for confounding factors. Each echocardiographic parameter, especially LVEF (left ventricular ejection fraction), was independently associated with A-FABP (all P<0.05). Multivariate logistic regression analysis demonstrated that A-FABP concentration was an independent risk factor for HF [odds ratio, 6.93 (95% confidence interval, 2.49-19.30); P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and raise the possibility that increased A-FABP may be causally related to the pathogenesis of heart dysfunction in humans. |
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Authors:
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Mingya Liu; Mi Zhou; Yuqian Bao; Zhiyong Xu; Huating Li; Hao Zhang; Wei Zhu; Jialiang Zhang; Aimin Xu; Meng Wei; Weiping Jia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 124 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: IM |
Affiliation:
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*Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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