| Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome. | |
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MedLine Citation:
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PMID: 22308843 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Adipocyte fatty acid-binding protein (A-FABP) links obesity and metabolic syndrome (MetS) and might be targeted in future therapies. Its utility as a MetS biomarker has been suggested in adults but has not been examined in children/adolescents. Our objectives were to identify metabolic parameters associated with A-FABP elevation in children and adolescents and to evaluate the effect of obesity intervention and A-FABP diagnostic utility. A-FABP and anthropometric, metabolic, and inflammatory indices were measured in 31 lean and 114 overweight/obese children and adolescents and reassessed after obesity intervention (1 year; diet and enhanced physical activity, with or without metformin). A-FABP was significantly higher in overweight/ obese than lean individuals, where it correlated with insulin, waist circumference (WC), and 2-h glucose independent of body mass index (BMI), age, gender, and developmental stage. The pattern of A-FABP associations differed between sexes. As a MetS indicator, A-FABP had 68% accuracy. The weight reduction program was effective in reducing A-FABP, BMI%, WC, triglycerides, and cholesterol. In conclusion, elevation in A-FABP is associated with MetS components independent of BMI status and can be reduced by diet and enhanced physical activity. A-FABP as a single MetS biomarker has a moderate accuracy. |
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Authors:
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Malgorzata Krzystek-Korpacka; Eliza Patryn; Iwona Bednarz-Misa; Magdalena Mierzchala; Katarzyna Hotowy; Elzbieta Czapinska; Irena Kustrzeba-Wojcicka; Andrzej Gamian; Anna Noczynska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 24 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: Germany |
Other Details:
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Languages: eng Pagination: 921-8 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry, Wroclaw Medical University, ul. Chalubinskiego 10, 50-368 Wroclaw, Poland. krzystek@bioch.am.wroc.pl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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