| Circulating vitamin D metabolites and kidney disease in type 1 diabetes. | |
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MedLine Citation:
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PMID: 22990096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Impaired vitamin D metabolism may contribute to the development and progression of diabetic kidney disease. OBJECTIVE: The aim of the study was to test associations of circulating vitamin D metabolites with risks of incident microalbuminuria, impaired glomerular filtration rate (GFR), and hypertension in type 1 diabetes. DESIGN: We performed a cohort study of 1193 participants in the Diabetes Control and Complications Trial (DCCT), a randomized clinical trial of intensive diabetes therapy, and its observational follow-up, the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. We measured plasma concentrations of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D by mass spectrometry at the end of the DCCT and tested associations with incident microalbuminuria, impaired GFR, and hypertension over up to 16 yr of EDIC follow-up. RESULTS: At the time metabolites were measured, mean age was 32.4 yr; mean duration of diabetes, 7.5 yr; mean iothalamate GFR, 132.9 ml/min/1.73 m(2); and geometric mean albumin excretion rate, 11.8 mg/24 h. Over follow-up, 166 cases of microalbuminuria, 54 cases of impaired GFR, and 541 cases of hypertension were observed. Compared with 25(OH)D of at least 30 ng/ml, 25(OH)D below 20 ng/ml was associated with a 65% higher risk of microalbuminuria (95% confidence interval, 7 to 154%) in adjusted analyses. Low concentrations of 24,25-dihydroxyvitamin D, but not 1,25-dihydroxyvitamin D, were also associated with increased risk of microalbuminuria. No circulating vitamin D metabolite was associated with risk of impaired GFR or hypertension. CONCLUSIONS: Low plasma concentrations of 25(OH)D and 24,25-dihydroxyvitamin D are associated with increased risk of microalbuminuria in type 1 diabetes. In contrast, we did not find evidence linking impaired vitamin D metabolism to early GFR loss or the development of hypertension. |
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Authors:
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Ian H de Boer; Michael C Sachs; Patricia A Cleary; Andrew N Hoofnagle; John M Lachin; Mark E Molitch; Michael W Steffes; Wanjie Sun; Bernard Zinman; John D Brunzell; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-09-18 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 97 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: 2013-02-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4780-8 Citation Subset: AIM; IM |
Affiliation:
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Kidney Research Institute and Division of Nephrology, University of Washington, Box 359606, 325 Ninth Avenue, Seattle, Washington 98104, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00360815; NCT00360893 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuminuria / blood, complications, epidemiology, metabolism Cohort Studies Diabetes Mellitus, Type 1 / blood*, complications, epidemiology, metabolism* Diabetic Nephropathies / blood*, complications, epidemiology, metabolism* Female Follow-Up Studies Glomerular Filtration Rate Humans Hypertension / blood, complications, epidemiology, metabolism Incidence Male Randomized Controlled Trials as Topic Vitamin D / analysis, blood*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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KL2 TR000421/TR/NCATS NIH HHS; P01DK02456/DK/NIDDK NIH HHS; P30DK035816/DK/NIDDK NIH HHS; R01DK088762/DK/NIDDK NIH HHS; R01HL096875/HL/NHLBI NIH HHS; RC4DK090766/DK/NIDDK NIH HHS; UL1 TR000423/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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