Document Detail


Circulating vascular growth factors and central hemodynamic load in the community.
MedLine Citation:
PMID:  22371357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mean and pulsatile components of hemodynamic load are related to cardiovascular disease. Vascular growth factors play a fundamental role in vascular remodeling. The links between growth factors and hemodynamic load components are not well described. In 3496 participants from the Framingham Heart Study third generation cohort (mean age: 40±9 years; 52% women), we related 4 tonometry-derived measures of central arterial load (carotid femoral pulse wave velocity and forward pressure wave, mean arterial pressure, and the global reflection coefficient) to circulating concentrations of angiopoietin 2, its soluble receptor; vascular endothelial growth factor, its soluble receptor; hepatocyte growth factor; insulin-like growth factor 1; and its binding protein 3. Using multivariable linear regression models, adjusted for standard cardiovascular risk factors, serum insulin-like growth factor 1 concentrations were negatively associated with carotid femoral pulse wave velocity, mean arterial pressure, and reflection coefficient (P≤0.01 for all), whereas serum vascular endothelial growth factor levels were positively associated with carotid femoral pulse wave velocity and mean arterial pressure (P<0.04). Serum insulin-like growth factor binding protein 3 and soluble angiopoietin 2 receptor levels were positively related to mean arterial pressure and to forward pressure wave, respectively (P<0.05). In our cross-sectional study of a large community-based sample, circulating vascular growth factor levels were related to measures of mean and pulsatile hemodynamic load in a pattern consistent with the known physiological effects of insulin-like growth factor 1 and vascular endothelial growth factor.
Authors:
Justin P Zachariah; Vanessa Xanthakis; Martin G Larson; Joseph A Vita; Lisa M Sullivan; Holly M Smith; Radwan Safa; Xuyang Peng; Naomi Hamburg; Daniel Levy; Douglas B Sawyer; Gary F Mitchell; Ramachandran S Vasan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-27
Journal Detail:
Title:  Hypertension     Volume:  59     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-05-08     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiopoietin-2 / blood
Biological Markers / blood
Blood Flow Velocity / physiology
Blood Pressure / physiology
Cardiovascular Diseases / blood*,  epidemiology*,  physiopathology
Cohort Studies
Cross-Sectional Studies
Female
Hemodynamics / physiology*
Humans
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / metabolism
Male
Middle Aged
Receptor, TIE-2 / blood
Risk Factors
Vascular Endothelial Growth Factors / blood*
Grant Support
ID/Acronym/Agency:
N01 HC025195/HC/NHLBI NIH HHS; N01-HC 25195/HC/NHLBI NIH HHS; N01HC25195/HL/NHLBI NIH HHS; R01 HL070100/HL/NHLBI NIH HHS; R01 HL070100-04/HL/NHLBI NIH HHS; R01 HL077447/HL/NHLBI NIH HHS; R01 HL077447-05/HL/NHLBI NIH HHS; R01-HL-077447/HL/NHLBI NIH HHS; R01-HL-70100/HL/NHLBI NIH HHS; T32 GM074905/GM/NIGMS NIH HHS; T32 HL-007572/HL/NHLBI NIH HHS; T32 HL007572-28/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiopoietin-2; 0/Biological Markers; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Vascular Endothelial Growth Factors; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, TIE-2
Comments/Corrections
Comment In:
Hypertension. 2012 Apr;59(4):769-70   [PMID:  22371358 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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