| Circulating vascular growth factors and central hemodynamic load in the community. | |
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MedLine Citation:
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PMID: 22371357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mean and pulsatile components of hemodynamic load are related to cardiovascular disease. Vascular growth factors play a fundamental role in vascular remodeling. The links between growth factors and hemodynamic load components are not well described. In 3496 participants from the Framingham Heart Study third generation cohort (mean age: 40±9 years; 52% women), we related 4 tonometry-derived measures of central arterial load (carotid femoral pulse wave velocity and forward pressure wave, mean arterial pressure, and the global reflection coefficient) to circulating concentrations of angiopoietin 2, its soluble receptor; vascular endothelial growth factor, its soluble receptor; hepatocyte growth factor; insulin-like growth factor 1; and its binding protein 3. Using multivariable linear regression models, adjusted for standard cardiovascular risk factors, serum insulin-like growth factor 1 concentrations were negatively associated with carotid femoral pulse wave velocity, mean arterial pressure, and reflection coefficient (P≤0.01 for all), whereas serum vascular endothelial growth factor levels were positively associated with carotid femoral pulse wave velocity and mean arterial pressure (P<0.04). Serum insulin-like growth factor binding protein 3 and soluble angiopoietin 2 receptor levels were positively related to mean arterial pressure and to forward pressure wave, respectively (P<0.05). In our cross-sectional study of a large community-based sample, circulating vascular growth factor levels were related to measures of mean and pulsatile hemodynamic load in a pattern consistent with the known physiological effects of insulin-like growth factor 1 and vascular endothelial growth factor. |
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Authors:
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Justin P Zachariah; Vanessa Xanthakis; Martin G Larson; Joseph A Vita; Lisa M Sullivan; Holly M Smith; Radwan Safa; Xuyang Peng; Naomi Hamburg; Daniel Levy; Douglas B Sawyer; Gary F Mitchell; Ramachandran S Vasan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-02-27 |
Journal Detail:
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Title: Hypertension Volume: 59 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-16 Completed Date: 2012-05-08 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 773-9 Citation Subset: IM |
Affiliation:
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Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702-5803, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiopoietin-2 / blood Biological Markers / blood Blood Flow Velocity / physiology Blood Pressure / physiology Cardiovascular Diseases / blood*, epidemiology*, physiopathology Cohort Studies Cross-Sectional Studies Female Hemodynamics / physiology* Humans Insulin-Like Growth Factor Binding Protein 3 / blood Insulin-Like Growth Factor I / metabolism Male Middle Aged Receptor, TIE-2 / blood Risk Factors Vascular Endothelial Growth Factors / blood* |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC025195/HC/NHLBI NIH HHS; N01-HC 25195/HC/NHLBI NIH HHS; N01HC25195/HL/NHLBI NIH HHS; R01 HL070100-04/HL/NHLBI NIH HHS; R01 HL077447-05/HL/NHLBI NIH HHS; R01-HL-077447/HL/NHLBI NIH HHS; R01-HL-70100/HL/NHLBI NIH HHS; T32 HL-007572/HL/NHLBI NIH HHS; T32 HL007572-28/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiopoietin-2; 0/Biological Markers; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Vascular Endothelial Growth Factors; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, TIE-2 |
| Comments/Corrections | |
Comment In:
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Hypertension. 2012 Apr;59(4):769-70
[PMID:
22371358
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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