Document Detail


Circulating TNFRI and TNFRII levels correlated with the disease activity score (DAS28) in rheumatoid arthritis.
MedLine Citation:
PMID:  19579138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure levels of soluble tumour necrosis factor alpha (TNFalpha) receptor type I (sTNFRI) and type II (sTNFRII) in order to correlate them with C-reactive protein (CRP), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), and disease activity score (DAS28) in RA patients. METHODS: We recruited 41 RA patients classified according to American College of Rheumatology (ACR) criteria and 38 healthy subjects (HS). sTNFRI and sTNFRII were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Clinical activity in RA patients was evaluated using the Disease Activity Score using 28 joint counts (DAS28). The statistical analysis was realized using SPSS version 10.0. RESULTS: Soluble TNFRI and TNFRII levels were higher in RA patients (p = 0.04 and 0.001, respectively) than HS. Serum levels of sTNFRI correlated with sTNFRII (r = 0.699, p < 0.0001). sTNFRII correlated with DAS28 (r = 0.375, p = 0.017), RF (r = 0.505, p = 0.004), and ESR (r = 0.323, p = 0.042). CONCLUSION: The increased levels of both sTNFRI and sTNFRII suggest a secondary event related to the inflammatory state observed in RA, whereas the correlation of sTNFRII with RF, ESR, and DAS28 reflects the preferential TNFRII shedding induced by TNFalpha. sTNFRII may be useful as an additional inflammatory marker in RA.
Authors:
Y Valle; I Y Ledezma-Lozano; N Torres-Carrillo; J R Padilla-Guti?rrez; R E Navarro-Hern?ndez; M V?zquez-Del Mercado; C A Palafox-S?nchez; J Armend?riz-Borunda; J F Mu?oz-Valle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  38     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2009  
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  332-5     Citation Subset:  IM    
Affiliation:
Institute for Rheumatology and Muscle-Skeletal Research, University of Guadalajara, Guadalajara, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Rheumatoid / blood*
Biological Markers / blood
Blood Sedimentation
C-Reactive Protein / metabolism
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Receptors, Tumor Necrosis Factor, Type I / blood*
Receptors, Tumor Necrosis Factor, Type II / blood*
Rheumatoid Factor / blood
Severity of Illness Index*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor

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