| Circulating TNF Receptors 1 and 2 Predict Stage 3 CKD in Type 1 Diabetes. | |
| | |
MedLine Citation:
|
PMID: 22266664 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 and TNFR2) predict development of ESRD in patients with type 2 diabetes without proteinuria, suggesting these markers may contribute to the pathogenesis of renal decline. We investigated whether circulating markers of the TNF pathway determine GFR loss among patients with type 1 diabetes. We followed two cohorts comprising 628 patients with type 1 diabetes, normal renal function, and no proteinuria. Over 12 years, 69 patients developed estimated GFR less than 60 mL/min per 1.73 m(2) (16 per 1000 person-years). Concentrations of TNFR1 and TNFR2 were strongly associated with risk for early renal decline. Renal decline was associated only modestly with total TNFα concentration and appeared unrelated to free TNFα. The cumulative incidence of estimated GFR less than 60 mL/min per 1.73 m(2) for patients in the highest TNFR2 quartile was 60% after 12 years compared with 5%-19% in the remaining quartiles. In Cox proportional hazards analysis, patients with TNFR2 values in the highest quartile were threefold more likely to experience renal decline than patients in the other quartiles (hazard ratio, 3.0; 95% confidence interval, 1.7-5.5). The risk associated with high TNFR1 values was slightly less than that associated with high TNFR2 values. TNFR levels were unrelated to baseline free TNFα level and remained stable over long periods within an individual. In conclusion, early GFR loss in patients with type 1 diabetes without proteinuria is strongly associated with circulating TNF receptor levels but not TNFα levels (free or total). |
| | |
Authors:
|
Tomohito Gohda; Monika A Niewczas; Linda H Ficociello; William H Walker; Jan Skupien; Florencia Rosetti; Xavier Cullere; Amanda C Johnson; Gordon Crabtree; Adam M Smiles; Tanya N Mayadas; James H Warram; Andrzej S Krolewski |
Related Documents
:
|
4095254 - Increased uptake of bone radiopharmaceutical in diabetic neuropathy. 21930854 - Relationship of urinary bisphenol a concentration to risk for prevalent type 2 diabetes... 21613784 - Weight change, blood pressure, lipids and glycemic control among patients with type 2 d... 21453154 - Glucose and insulin dynamics associated with continuous rate infusion of dextrose solut... 3240844 - Blood glucose may condition factor vii levels in diabetic and normal subjects. 3757764 - Prostaglandin e1 incorporated in lipid microspheres in the treatment of peripheral vasc... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
|
Title: Journal of the American Society of Nephrology : JASN Volume: - ISSN: 1533-3450 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
*Research Division, Joslin Diabetes Center and. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Circulating TNF Receptors 1 and 2 Predict ESRD in Type 2 Diabetes.
Next Document: Trends in acute nonvariceal upper gastrointestinal bleeding in dialysis patients.